Evidence mapPaperPMID 39199658Full record

GuidelineCancers2024

Evolving and Improving the Sustainability of Molecular Tumor Boards: The Value and Challenges.

Marius Bartels, Benoist Chibaudel, Rodrigo Dienstmann, Janne Lehtiö, Alberta Piccolo, Olivier Michielin, Grainne O'Kane, Giancarlo Pruneri

Abstract readGuideline
In one paragraph

Guideline in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marius BartelsDepartment of Medical Oncology, Praxis für Onkologie Mönchengladbach, 41066 Mönchengladbach, Germany.ORCID 0009-0001-5225-0146
Benoist ChibaudelDepartment of Medical Oncology, Hôpital Franco-Britannique-Fondation Cognacq-Jay, Cancérologie ParisOuest, 92300 Levallois-Perret, France.
Rodrigo DienstmannOncology Data Science (ODysSey) Group, Vall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
Janne LehtiöScience for Life Laboratory and Karolinska Comprehensive Cancer Center, Department of Oncology and Pathology, Karolinska Institutet, 17177 Solna, Sweden.
Alberta PiccoloPathology Unit 2, Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.ORCID 0000-0003-2078-9988
Olivier MichielinDepartment of Oncology and the Precision Oncology Service, Geneva University Hospital, 1205 Geneva, Switzerland.
Grainne O'KaneTrinity St. James's Cancer Institute, St. James's Hospital, D08 NHY1 Dublin, Ireland.
Giancarlo PruneriPathology Unit 2, Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing volume of information for cancer care, and the evolution of molecularly guided therapies, have increased the need for molecular tumor boards (MTBs), which can integrate such data into personalized treatment plans to improve patient outcomes. However, recommendations for improving the sustainability of MTBs are lacking. A diverse committee of MTB experts was assembled (February-March 2023), with extensive experience in sustainability in healthcare ecosystems. The aim was to identify MTB-related hurdles throughout the patient journey and develop a general framework for MTBs to operate on larger scales locally, nationally, and internationally. The committee identified ten key pillars for sustainable and scalable MTBs, including technical solutions for data integration and visualization, interoperability, learning loops, clinical trial access, legal considerations, criteria for patient testing, decision standardization, making MTBs official bodies for treatment decisions, local leaders, and international networks. The need for scalable frameworks at academic and community levels was recognized, along with integrating MTBs into national health systems to enhance sustainability and ensure optimal treatment decisions. Irrespective of the health ecosystem, the sustainability and scalability of MTBs are essential. Our framework provides guidelines to address this and to help MTBs evolve towards integrated, essential components of the oncology healthcare system.

Indexed as

molecularly guided therapymolecular tumor boardprecision oncologyrecommendationssustainability

Identifiers

PMID39199658
PMCPMC11353190

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.