Evidence map›Paper›PMID 39199751›Full record

ReviewBioengineering (Basel, Switzerland)2024

Muscle Synergy Analysis as a Tool for Assessing the Effectiveness of Gait Rehabilitation Therapies: A Methodological Review and Perspective.

Daniele Borzelli, Cristiano De Marchis, Angelica Quercia, Paolo De Pasquale, Antonino Casile, Angelo Quartarone, Rocco Salvatore Calabrò, Andrea d'Avella

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Bioengineering of the Motor System.Bioengineering (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniele BorzelliDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-9456-0177
Cristiano De MarchisEngineering Department, University of Messina, Messina 98166, Italy.ORCID 0000-0003-1522-7454
Angelica QuerciaDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-7121-0692
Paolo De PasqualeIRCCS Centro Neurolesi "Bonino Pulejo", 98124 Messina, Italy.ORCID 0000-0003-1688-2151
Antonino CasileDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi "Bonino Pulejo", 98124 Messina, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi "Bonino Pulejo", 98124 Messina, Italy.ORCID 0000-0002-8566-3166
Andrea d'AvellaLaboratory of Neuromotor Physiology, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.ORCID 0000-0002-3393-4956

Funding

American Ministry of Defense (DoD Grant) W81XWH-19-1-0810
6 · The paper itself

Abstract

According to the modular hypothesis for the control of movement, muscles are recruited in synergies, which capture muscle coordination in space, time, or both. In the last two decades, muscle synergy analysis has become a well-established framework in the motor control field and for the characterization of motor impairments in neurological patients. Altered modular control during a locomotion task has been often proposed as a potential quantitative metric for characterizing pathological conditions. Therefore, the purpose of this systematic review is to analyze the recent literature that used a muscle synergy analysis of neurological patients' locomotion as an indicator of motor rehabilitation therapy effectiveness, encompassing the key methodological elements to date. Searches for the relevant literature were made in Web of Science, PubMed, and Scopus. Most of the 15 full-text articles which were retrieved and included in this review identified an effect of the rehabilitation intervention on muscle synergies. However, the used experimental and methodological approaches varied across studies. Despite the scarcity of studies that investigated the effect of rehabilitation on muscle synergies, this review supports the utility of muscle synergies as a marker of the effectiveness of rehabilitative therapy and highlights the challenges and open issues that future works need to address to introduce the muscle synergies in the clinical practice and decisional process.

Indexed as

brain tumorcerebral palsymotor coordinationmotor modulesmultiple sclerosismusculo-skeletal redundancymyelopathyneural diseaseParkinson’s diseasestroke

Identifiers

PMID39199751
PMCPMC11351442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.