Evidence map›Paper›PMID 39200045›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Nosocomial Bacteria Inhibition with Polymyxin B: In Silico Gene Mining and In Vitro Analysis.

Jayendra Chunduru, Nicholas LaRoe, Jeremy Garza, Abdul N Hamood, Paul W Paré

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jayendra ChunduruChemistry & Biochemistry Department, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-8059-2629
Nicholas LaRoeChemistry & Biochemistry Department, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0009-0007-7403-2389
Jeremy GarzaDepartment of Immunology & Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Abdul N HamoodDepartment of Immunology & Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0001-7193-7827
Paul W ParéChemistry & Biochemistry Department, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0003-1644-723X

Funding

Texas Tech University Presidential Research Fund TTU 2024
6 · The paper itself

Abstract

Multidrug-resistant bacteria present a significant public health challenge; such pathogens exhibit reduced susceptibility to conventional antibiotics, limiting current treatment options. Cationic non-ribosomal peptides (CNRPs) such as brevicidine and polymyxins have emerged as promising candidates to block Gram-negative bacteria. To investigate the capability of bacteria to biosynthesize CNRPs, and specifically polymyxins, over 11,000 bacterial genomes were mined in silico.

Indexed as

biosynthesiscationic non-ribosomal peptidesmultidrug-resistant bacteriapolymyxin B

Identifiers

PMID39200045
PMCPMC11350920

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.