Evidence mapPaperPMID 39200102Full record

ArticleBiomedicines2024

Mitochondrial Genome-Encoded Long Noncoding RNA

Jay Kumar, Pooja Malaviya, Renu A Kowluru

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jay KumarOphthalmology, Visual and Anatomical Sciences, Wayne State University, 4717 St. Antoine, Detroit, MI 48201, USA.
Pooja MalaviyaOphthalmology, Visual and Anatomical Sciences, Wayne State University, 4717 St. Antoine, Detroit, MI 48201, USA.
Renu A KowluruOphthalmology, Visual and Anatomical Sciences, Wayne State University, 4717 St. Antoine, Detroit, MI 48201, USA.ORCID 0000-0002-3309-4942

Funding

Pilot and Feasibility ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$4.9M
Role of Ras in Retinal Cell Death in DiabetesR01EY014370 · WAYNE STATE UNIVERSITY · 2004 to 2005
$525k
Diabetic Retinopathy, Mitochondria Damage and Long Non-coding RNAsR01EY033516 · WAYNE STATE UNIVERSITY · 2025 to 2025
$347k
NEI NIH HHS R01 EY014370NEI NIH HHS R01 EY017313NEI NIH HHS R01 EY033516NIDDK NIH HHS P30 DK020572NIH HHS EY014370, EY017313, and EY033516
6 · The paper itself

Abstract

aimHyperglycemia damages mitochondria and downregulates transcription of mtDNA-encoded genes and the long noncoding RNA Lnc

methodsUsing human retinal endothelial cells incubated in 20 mM D-glucose for 96 h, the gene expression and mitochondrial localization (immunofluorescence) of MRPP1 and the interaction between MRPP1 and Lnc

resultsCompared to normal glucose, high glucose decreased mRNA and mitochondrial localization of MRPP1 and its interaction with Lnc

conclusionsDownregulation of MRPP1 in diabetes suppresses Lnc

Indexed as

diabetic retinopathyLncCytBlong noncoding RNAmitochondriamitochondrial ribonuclease P

Identifiers

PMID39200102
PMCPMC11351977

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.