Evidence mapPaperPMID 39200115Full record

ReviewBiomedicines2024

Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism.

Vincenzo Quagliariello, Maria Laura Canale, Irma Bisceglia, Carlo Maurea, Domenico Gabrielli, Luigi Tarantini, Andrea Paccone, Alessandro Inno, Stefano Oliva, Christian Cadeddu Dessalvi and 5 more

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vincenzo QuagliarielloDivision of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Napoli, Italy.ORCID 0000-0002-4557-5401
Maria Laura CanaleU.O.C. Cardiologia, Ospedale Versilia, 55041 Lido di Camaiore, Italy.
Irma BiscegliaServizi Cardiologici Integrati, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliera San Camillo Forlanini, 00152 Roma, Italy.ORCID 0000-0002-0689-0695
Carlo MaureaNeurology Department, University of Salerno, 84084 Fisciano, Italy.
Domenico GabrielliU.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliera San Camillo Forlanini, 00152 Roma, Italy.ORCID 0000-0003-3392-0527
Luigi TarantiniDivisione di Cardiologia, Arcispedale S. Maria Nuova, Azienda Unità Sanitaria Locale-IRCCS di Reggio-Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0003-2580-0963
Andrea PacconeDivision of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Napoli, Italy.
Alessandro InnoMedical Oncology, IRCCS Ospedale Sacro Cuore Don Calabria, 37024 Negrar di Valpolicella, Italy.ORCID 0000-0001-6331-6908
Stefano OlivaUOSD Cardiologia di Interesse Oncologico IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
Christian Cadeddu DessalviDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-2823-1797
Concetta ZitoCardiology Division, University Hospital Polyclinic G. Martino, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-6908-4316
Michele CaragliaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 7, 80138 Naples, Italy.ORCID 0000-0003-2408-6091
Massimiliano BerrettaDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-9837-9148
Giuseppe D'AiutoClinica C.G. Ruesch, 80122 Naples, Italy.
Nicola MaureaDivision of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Napoli, Italy.ORCID 0000-0003-3704-0092

Funding

Ministero della Salute, Ricerca Corrente Ricerca Corrente Grant, Ministero della Salute, Linea 6/1 "Cardiotossicità da chemioterapie, targeted therapies e immunoterapie, diagnosi precoce e cardioprotezione. Ricerca preclinica e clinica"
6 · The paper itself

Abstract

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in the world. The emerging field of cardio-oncology described several shared risk factors that predispose patients to both cardiovascular disease and cancer. Post-acute COVID-19 syndrome is a chronic condition that occurs in many patients who have experienced a SARS-CoV-2 infection, mainly based on chronic fatigue, sedentary lifestyle, cramps, breathing difficulties, and reduced lung performance. Post-acute COVID-19 exposes patients to increased visceral adiposity, insulin resistance, myosteatosis, and white adipose tissue content (surrounded by M1 macrophages and characterized by a Th1/Th17 phenotype), which increases the risk of cardiovascular mortality and cancer recurrence. In this review, the main metabolic affections of post-acute COVID-19 syndrome in cancer patients at low and high risk of cardiomyopathies will be summarized. Furthermore, several non-pharmacological strategies aimed at reducing atherosclerotic and cardiac risk will be provided, especially through anti-inflammatory nutrition with a low insulin and glycemic index, appropriate physical activity, and immune-modulating bioactivities able to reduce visceral obesity and myosteatosis, improving insulin-related signaling and myocardial metabolism.

Indexed as

cancercardio-oncologycardiotoxicityCOVID-19inflammationmetabolism

Identifiers

PMID39200115
PMCPMC11351439

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.