Evidence map›Paper›PMID 39200330›Full record

ArticleBiomedicines2024

Use of Non-Thermal Plasma as Postoperative Therapy in Anal Fistula: Clinical Experience and Results.

Régulo López-Callejas, Pasquinely Salvador Velasco-García, Mario Betancourt-Ángeles, Benjamín Gonzalo Rodríguez-Méndez, Guillermo Berrones-Stringel, César Jaramillo-Martínez, Fernando Eliseo Farías-López, Antonio Mercado-Cabrera, Raúl Valencia-Alvarado

Registry-linked trialAbstract read
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In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07656818 (Application of Non-Thermal Plasma in the Surgical Bed of Chronic Subdural Hematoma to Reduce the Post-Drainage Recurrence Rate), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07656818 narecruitingnot on this mapstarted 2026, after this paper: background citation

Application of Non-Thermal Plasma in the Surgical Bed of Chronic Subdural Hematoma to Reduce the Post-Drainage Recurrence Rate: A Randomized Controlled Trial

TypeinterventionalSponsorBenjamín Gonzalo Rodríguez MéndezRan2026 to 2027Enrolled40ConditionsChronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative ComplicationsArmsStandard Surgery Protocol, Non-Thermal Plasma
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Régulo López-CallejasPlasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac 52750, Mexico.ORCID 0000-0003-3645-4373
Pasquinely Salvador Velasco-GarcíaMedical Center ISSEMyM Toluca, Av. Baja velocidad 284 km. 57.5, San Jerónimo Chicahualco, Metepec 52170, Mexico.
Mario Betancourt-ÁngelesMedical Center ISSEMyM Toluca, Av. Baja velocidad 284 km. 57.5, San Jerónimo Chicahualco, Metepec 52170, Mexico.
Benjamín Gonzalo Rodríguez-MéndezPlasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac 52750, Mexico.ORCID 0000-0002-0495-9118
Guillermo Berrones-StringelMedical Center ISSEMyM Toluca, Av. Baja velocidad 284 km. 57.5, San Jerónimo Chicahualco, Metepec 52170, Mexico.
César Jaramillo-MartínezMedical Center ISSEMyM Toluca, Av. Baja velocidad 284 km. 57.5, San Jerónimo Chicahualco, Metepec 52170, Mexico.
Fernando Eliseo Farías-LópezMedical Center ISSEMyM Toluca, Av. Baja velocidad 284 km. 57.5, San Jerónimo Chicahualco, Metepec 52170, Mexico.
Antonio Mercado-CabreraPlasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac 52750, Mexico.ORCID 0000-0001-7450-0014
Raúl Valencia-AlvaradoPlasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac 52750, Mexico.

Funding

National Nuclear Research Institute, Mexico CB-302
6 · The paper itself

Abstract

Anal fistula, characterized by abnormal tracts between the perianal skin and the anal canal, presents challenges in treatment because of its diversity and complexity. This study investigates the use of non-thermal plasma as a postsurgical therapy for anal fistula, aiming to promote healing and tissue regeneration. A specialized plasma reactor was designed to apply non-thermal plasma within the anorectal cavity practically. Non-thermal plasma treatment was administered to 20 patients including 10 undergoing fistulectomies and 10 undergoing fistulotomies. The average duration of non-thermal plasma application in the operating room was shorter for fistulotomies. The pain reported the day after surgery was similar in both groups. Improvements in the number of evacuations starting from the day after surgery, as well as the assessment of stool quality using the Bristol scale, indicated satisfactory intestinal recovery. Fistulotomy patients exhibited faster wound healing times. These findings underscore the efficacy of non-thermal plasma as a postoperative therapy for anal fistula, enhancing healing and recovery outcomes without increasing complication risks.

Indexed as

anal fistulafistulectomyfistulotomynon-thermal plasmawound healing

Identifiers

PMID39200330
PMCPMC11351551

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.