Evidence map›Paper›PMID 39200575›Full record

ArticleInternational journal of environmental research and public health2024

PON1 Status in Relation to Gulf War Illness: Evidence of Gene-Exposure Interactions from a Multisite Case-Control Study of 1990-1991 Gulf War Veterans.

Lea Steele, Clement E Furlong, Rebecca J Richter, Judit Marsillach, Patricia A Janulewicz, Maxine H Krengel, Nancy G Klimas, Kimberly Sullivan, Linda L Chao

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lea SteeleVeterans Health Research Program, Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Clement E FurlongDepartment of Medicine (Division Medical Genetics), University of Washington, Seattle, WA 98195, USA.
Rebecca J RichterDepartment of Medicine (Division Medical Genetics), University of Washington, Seattle, WA 98195, USA.ORCID 0009-0006-3806-735X
Judit MarsillachDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0002-3061-6266
Patricia A JanulewiczDepartment of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.
Maxine H KrengelDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Nancy G KlimasDr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 22238, USA.ORCID 0000-0003-1459-3268
Kimberly SullivanDepartment of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0001-7940-6123
Linda L ChaoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94142, USA.ORCID 0000-0002-8593-2434

Funding

Congressionally Directed Medical Research Programs W81XWH-16-1-0558Congressionally Directed Medical Research Programs W81XWH-18-1-0549CSRD VA IK6 CX002522
6 · The paper itself

Abstract

backgroundDeployment-related neurotoxicant exposures are implicated in the etiology of Gulf War illness (GWI), the multisymptom condition associated with military service in the 1990-1991 Gulf War (GW). A Q/R polymorphism at position 192 of the paraoxonase (PON)-1 enzyme produce PON1

methodsWe evaluated PON1

resultsHearing chemical alarms (proxy for possible nerve agent exposure) was associated with GWI only among RR status veterans (OR = 8.60,

conclusionStudy results suggest a complex pattern of PON1

Indexed as

AryldialkylphosphataseGulf WarPersian Gulf SyndromeVeteransAdultCase-Control StudiesCholinesterase InhibitorsFemaleHumansLogistic ModelsMaleMiddle AgedOccupational ExposurePesticidesPolymorphism, GeneticUnited StatesAryldialkylphosphataseCholinesterase InhibitorsPesticidesPON1 protein, humandeployment-related exposuresgene–environment interactionGulf War illnessGulf War veteransorganophosphatepesticidesPON1pyridostigmine bromide

Identifiers

PMID39200575
PMCPMC11353671

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.