Evidence map›Paper›PMID 39200711›Full record

ArticleInternational journal of environmental research and public health2024

Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort.

Ayushi Trivedi, Dipro Bose, Kelly Moffat, Elisabeth Pearson, Dana Walsh, Devra Cohen, Jonathan Skupsky, Linda Chao, Julia Golier, Patricia Janulewicz and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ayushi TrivediEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Dipro BoseEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Kelly MoffatCosmosID, Germantown, MD 20874, USA.
Elisabeth PearsonCosmosID, Germantown, MD 20874, USA.
Dana WalshCosmosID, Germantown, MD 20874, USA.ORCID 0000-0002-8919-0079
Devra CohenMiami VA Healthcare System, Miami, FL 33125, USA.ORCID 0000-0001-8469-967X
Jonathan SkupskyVA Research and Development, VA Long Beach Health Care, Long Beach, CA 90822, USA.
Linda ChaoSan Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.
Julia GolierJ. Peters VA Medical Center, Bronx, NY 10468, USA.
Patricia JanulewiczDepartment of Environmental Health, Boston University School of Public Health, 715 Albany St. T4W, Boston, MA 02130, USA.
Kimberly SullivanDepartment of Environmental Health, Boston University School of Public Health, 715 Albany St. T4W, Boston, MA 02130, USA.ORCID 0000-0001-7940-6123
Maxine KrengelDepartment of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02130, USA.
Ashok TutejaDivision of Gastroenterology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Nancy KlimasInstitute for Neuro-Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.ORCID 0000-0003-1459-3268
Saurabh ChatterjeeEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-1649-7149

Funding

CSRD VA I01 CX001923CSRD VA IK6 CX002522United States Department of Defense GW170055United States Department of Veterans Affairs 101CX0001923
6 · The paper itself

Abstract

Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990-1991 Gulf War. Fatigue, GI complaints, and other chronic symptoms continue to persist more than 30 years post-deployment. Several potential mechanisms for the persistent illness have been identified and our prior pilot study linked an altered gut microbiome with the disorder. This study further validates and builds on our prior preliminary findings of host gut microbiome dysbiosis in veterans with GWI. Using stool samples and Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases and 26 controls) from the Boston biorepository, recruitment, and integrative network (BBRAIN) for Gulf War Illness, we found that the host gut bacterial signature of veterans with GWI showed significantly different Bray-Curtis beta diversity than control veterans. Specifically, a higher

Indexed as

DysbiosisGastrointestinal MicrobiomePersian Gulf SyndromeVeteransAdultBacteriaBostonCohort StudiesFecesFemaleHumansMaleMiddle Agedbacterial metabolismbacteriomechronic fatigueCoprococcusEisenbergiellaGulf War IllnessLachnospiraceaeMultidimensional Fatigue Inventoryveteran

Identifiers

PMID39200711
PMCPMC11354743

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.