Evidence map›Paper›PMID 39201315›Full record

ArticleInternational journal of molecular sciences2024

Alterations in Tumor Aggression Following Androgen Receptor Signaling Restoration in Canine Prostate Cancer Cell Lines.

Demitria M Vasilatis, Neelu Batra, Christopher A Lucchesi, Christine J Abria, Eva-Maria Packeiser, Hugo Murua Escobar, Paramita M Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Demitria M VasilatisDepartment of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USA.ORCID 0000-0003-2001-6141
Neelu BatraVeterans Affairs (VA)-Northern California Healthcare System, Mather, CA 95655, USA.ORCID 0000-0002-8924-2297
Christopher A LucchesiDepartment of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USA.ORCID 0000-0001-8767-7003
Christine J AbriaVeterans Affairs (VA)-Northern California Healthcare System, Mather, CA 95655, USA.
Eva-Maria PackeiserDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0001-6694-3851
Hugo Murua EscobarDepartment of Medicine, Medical Clinic III, Hematology Oncology and Palliative Medicine, University Medical Center Rostock, 18057 Rostock, Germany.ORCID 0000-0001-7123-7986
Paramita M GhoshDepartment of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USA.ORCID 0000-0002-7304-2936

Funding

Comparative Medical Science Training ProgramT32OD011147 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JEROEN SAEIJ, Sara Michelle Thomasy · 2012 to 2026
$5.5M
NIH HHS NIH T32 OD011147NIH HHS T32 OD011147
6 · The paper itself

Abstract

In prostate cancer (PCa), androgens upregulate tumorigenesis, whereas in benign tissue, the revival of androgen receptor (AR) signaling suppresses aggressive behaviors, suggesting therapeutic potential. Dogs, natural PCa models, often lack AR in PCa. We restored AR in dog PCa to investigate resultant characteristics. Three AR-null canine PCa lines (1508, Leo, 1258) were transfected with canine wild-type AR and treated with dihydrotestosterone (DHT). In 1508, AR restoration decreased clonogenicity (

Indexed as

Cell MovementEpithelial-Mesenchymal TransitionProstatic NeoplasmsReceptors, AndrogenSignal TransductionAnimalsCell Line, TumorCell ProliferationDogsGene Expression Regulation, NeoplasticMaleNeoplasm InvasivenessReceptors, Androgenandrogen indifferent prostate cancerandrogen receptordogprostate cancer

Identifiers

PMID39201315
PMCPMC11354774

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.