Evidence mapPaperPMID 39201408Full record

ArticleInternational journal of molecular sciences2024

Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study.

Kacper Kamiński, Małgorzata Blatkiewicz, Marta Szyszka, Anna Olechnowicz, Hanna Komarowska, Anna Klimont, Tomasz Wierzbicki, Marek Karczewski, Marek Ruchała, Marcin Rucinski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kacper KamińskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0003-0641-1444
Małgorzata BlatkiewiczDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0001-5506-2397
Marta SzyszkaDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0003-0150-3665
Anna OlechnowiczDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0001-6043-5637
Hanna KomarowskaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-356 Poznan, Poland.ORCID 0000-0001-9085-4330
Anna KlimontDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-356 Poznan, Poland.
Tomasz WierzbickiDepartment of General, Endocrinological and Gastroenterological Surgery, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Marek KarczewskiDepartment of General and Transplantation Surgery, Poznan University of Medical Sciences, 60-356 Poznan, Poland.
Marek RuchałaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-356 Poznan, Poland.ORCID 0000-0002-6296-7220
Marcin RucinskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0002-2525-5777

Funding

National Science Centre in Poland 2020/38/E/NZ4/00020
6 · The paper itself

Abstract

Adrenal tumors, such as adrenocortical carcinoma (ACC), adrenocortical adenoma (ACA), and pheochromocytoma (PCC) are complex diseases with unclear causes and treatments. Mitochondria and mitochondrial-derived peptides (MDPs) are crucial for cancer cell survival. The primary aim of this study was to analyze samples from different adrenal diseases, adrenocortical carcinoma, adrenocortical adenoma, and pheochromocytoma, and compare them with normal adrenal tissue to determine whether the expression levels of the mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) gene and protein vary between different types of adrenal tumors compared to healthy controls using qPCR, ELISA, and IHC methods. Results showed decreased

Indexed as

Adrenal Gland NeoplasmsPheochromocytomaAdrenocortical AdenomaAdrenocortical CarcinomaAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMitochondrial ProteinsRNA, MessengerBiomarkers, TumorMitochondrial ProteinsMOTS-c peptide, humanRNA, Messengeradrenal tumorsmitochondria homeostasisMOTS-c

Identifiers

PMID39201408
PMCPMC11354279

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.