The Food Additive Benzaldehyde Confers a Broad Antibiotic Tolerance by Modulating Bacterial Metabolism and Inhibiting the Formation of Bacterial Flagella.

Xia Xiao, Can Ma, Han Zhang, Wei Liu, Yanhu Huang, Chuang Meng, Zhiqiang Wang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Metabolic state-driven nutrient-based approach to combat bacterial antibiotic resistance.npj antimicrobials and resistance · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xia XiaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Can MaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Han ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Wei LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Yanhu HuangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Chuang MengJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.

Zhiqiang WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0001-6486-9600

Funding

the National Natural Science Foundation of China 32273055, 32373061

6 · The paper itself

Abstract

The rise of antibiotic tolerance in bacteria harboring genetic elements conferring resistance to antibiotics poses an increasing threat to public health. However, the primary factors responsible for the emergence of antibiotic tolerance and the fundamental molecular mechanisms involved remain poorly comprehended. Here, we demonstrate that the commonly utilized food additive Benzaldehyde (BZH) possesses the capacity to induce a significant level of fluoroquinolone tolerance in vitro among resistant

Indexed as

Anti-Bacterial AgentsBenzaldehydesEscherichia coliFlagellaAnimalsCiprofloxacinDrug Resistance, BacterialFood AdditivesMiceMicrobial Sensitivity TestsReactive Oxygen SpeciesAnti-Bacterial AgentsbenzaldehydeBenzaldehydesCiprofloxacinFood AdditivesReactive Oxygen SpeciesantibioticbenzaldehydeciprofloxacinEscherichia colitolerance

Identifiers

PMID39201530

DOI10.3390/ijms25168843

PMCPMC11354442

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.