Evidence map›Paper›PMID 39201534›Full record

ArticleInternational journal of molecular sciences2024

Albiflorin Decreases Glutamate Release from Rat Cerebral Cortex Nerve Terminals (Synaptosomes) through Depressing P/Q-Type Calcium Channels and Protein Kinase A Activity.

Cheng-Wei Lu, Tzu-Yu Lin, Ya-Ying Chang, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheng-Wei LuDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-2217-3231
Tzu-Yu LinDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-1374-5189
Ya-Ying ChangDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.
Kuan-Ming ChiuDivision of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-7597-7655
Ming-Yi LeeDepartment of Medical Research, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0001-7742-9508
Su-Jane WangSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0002-4675-0259

Funding

Far Eastern Memorial Hospital, Taiwan 112-FEMH-FJU-01Far Eastern Memorial Hospital, Taiwan FEMH-2023-C-075Far Eastern Memorial Hospital, Taiwan FEMH-2023-C-076National Science and Technology Council, Taiwan 111-2314-B-418-009-MY2National Science and Technology Council, Taiwan 12-2320-B-030-010-MY3
6 · The paper itself

Abstract

The purpose of this study was to investigate whether and how albiflorin, a natural monoterpene glycoside, affects the release of glutamate, one of the most important neurotransmitters involved in neurotoxicity, from cerebrocortical nerve terminals (synaptosomes) in rats. The results showed that albiflorin reduced 4-aminopyridine (4-AP)-elicited glutamate release from synaptosomes, which was abrogated in the absence of extracellular Ca

Indexed as

Cerebral CortexCyclic AMP-Dependent Protein KinasesGlutamic AcidSynaptosomesAnimalsBridged-Ring CompoundsCalciumCalcium Channels, P-TypeCalcium Channels, Q-TypeGlycosidesMalePhosphorylationRatsRats, Sprague-DawleySynapsinsalbiflorinBridged-Ring CompoundsCalciumCalcium Channels, P-TypeCalcium Channels, Q-TypeCyclic AMP-Dependent Protein KinasesGlutamic AcidGlycosidesSynapsinsalbiflorinCa2+ channelglutamate release inhibitionPKAsynaptosome

Identifiers

PMID39201534
PMCPMC11354331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.