Evidence map›Paper›PMID 39201538›Full record

ArticleInternational journal of molecular sciences2024

Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis.

Enrica Torretta, Manuela Moriggi, Daniele Capitanio, Carlotta Perucca Orfei, Vincenzo Raffo, Stefania Setti, Ruggero Cadossi, Laura de Girolamo, Cecilia Gelfi

Registry-linked trialAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07495254 (Effectiveness of Combined Super Inductive System), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07495254 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Combined Super Inductive System (SIS) Therapy With Therapeutic Physical Therapy Exercise and Health Education in Lateral Elbow Tendinopathy

TypeinterventionalSponsorUniversity of Vic - Central University of CataloniaRan2026 to 2028Enrolled224ConditionsLateral Epicondylitis (Tennis Elbow), Lateral Epicondylalgia, Lateral Elbow TendinopathyArmsSuper Inductive System (SIS), therapeutic dose, Super Inductive System (SIS), non-therapeutic dose (active placebo), Therapeutic Exercise Program, Health Education
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Enrica TorrettaLaboratory of Proteomics and Lipidomics, IRCCS Orthopedic Institute Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-6374-3325
Manuela MoriggiDepartment of Biomedical Sciences for Health, University of Milan, 20090 Segrate, Italy.ORCID 0000-0002-4718-0307
Daniele CapitanioDepartment of Biomedical Sciences for Health, University of Milan, 20090 Segrate, Italy.ORCID 0000-0001-7701-728X
Carlotta Perucca OrfeiOrthopaedic Biotechnology Laboratory, IRCCS Orthopedic Institute Galeazzi, 20161 Milan, Italy.
Vincenzo RaffoOrthopaedic Biotechnology Laboratory, IRCCS Orthopedic Institute Galeazzi, 20161 Milan, Italy.ORCID 0009-0004-4658-722X
Stefania SettiIGEA Clinical Biophysics, 41012 Carpi, Italy.ORCID 0000-0001-8990-5452
Ruggero CadossiIGEA Clinical Biophysics, 41012 Carpi, Italy.
Laura de GirolamoOrthopaedic Biotechnology Laboratory, IRCCS Orthopedic Institute Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-9979-3092
Cecilia GelfiLaboratory of Proteomics and Lipidomics, IRCCS Orthopedic Institute Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-2996-6912

Funding

Italian Ministry of Health Ricerca Corrente
6 · The paper itself

Abstract

Tendon disorders often result in decreased muscle function and atrophy. Pulsed Electromagnetic Fields (PEMFs) have shown potential in improving tendon fiber structure and muscle recovery. However, the molecular effects of PEMF therapy on skeletal muscle, beyond conventional metrics like MRI or markers of muscle decline, remain largely unexplored. This study investigates the metabolic and structural changes in PEMF-treated muscle tissue using proteomics in a rat model of Achilles tendinopathy induced by collagenase. Sprague Dawley rats were unilaterally induced for tendinopathy with type I collagenase injection and exposed to PEMFs for 8 h/day.

Indexed as

CollagenasesDisease Models, AnimalMagnetic Field TherapyMuscle, SkeletalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProteomeRats, Sprague-DawleyTendinopathyAnimalsElectromagnetic FieldsGlycolysisMaleProteomicsRatsYAP-Signaling ProteinsCollagenasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratProteomeYap1 protein, ratYAP-Signaling ProteinsPEMFproteomicsrecoveryskeletal muscletendinopathy

Identifiers

PMID39201538
PMCPMC11354614

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.