Evidence map›Paper›PMID 39201617›Full record

ReviewInternational journal of molecular sciences2024

Nanoparticles-Delivered Circular RNA Strategy as a Novel Antitumor Approach.

Luisa Racca, Elisabetta Liuzzi, Simona Comparato, Giorgia Giordano, Ymera Pignochino

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luisa RaccaDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0003-2344-1047
Elisabetta LiuzziPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0009-0000-7369-1832
Simona ComparatoDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0009-0004-8412-7101
Giorgia GiordanoCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.ORCID 0000-0003-0177-4430
Ymera PignochinoDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0001-5073-8618

Funding

Fondazione CRT ROL 76069-2021
6 · The paper itself

Abstract

Anticancer therapy urgently needs the development of novel strategies. An innovative molecular target is represented by circular RNAs (circRNAs), single-strand RNA molecules with the 5' and 3' ends joined, characterized by a high stability. Although circRNA properties and biological functions have only been partially elucidated, their relationship and involvement in the onset and progression of cancer have emerged. Specific targeting of circRNAs may be obtained with antisense oligonucleotides and silencing RNAs. Nanotechnology is at the forefront of research for perfecting their delivery. Continuous efforts have been made to develop novel nanoparticles (NPs) and improve their performance, materials, and properties regarding biocompatibility and targeting capabilities. Applications in various fields, from imaging to gene therapy, have been explored. This review sums up the smart strategies developed to directly target circRNAs with the fruitful application of NPs in this context.

Indexed as

NanoparticlesNeoplasmsRNA, CircularAnimalsAntineoplastic AgentsGenetic TherapyHumansAntineoplastic AgentsRNA, Circularcancer therapycircRNAcircRNA-based therapeuticdrug deliverygene therapynanomaterialnanomedicinenanoparticlestheranostics

Identifiers

PMID39201617
PMCPMC11354327

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.