Evidence map›Paper›PMID 39201719›Full record

ArticleInternational journal of molecular sciences2024

A Bioinformatics-Based Study on Methylation Alterations of the FBLN1 Gene in Hippocampal Tissue of Alzheimer's Disease Model DKO and DTG Mice.

Rui Tang, Yue Jian, Zhimin Hu, Li Li, Haitao Wang, Pengyu Miao, Zhihui Yang, Mingxi Tang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui TangSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Yue JianSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.ORCID 0009-0009-9868-0959
Zhimin HuSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.ORCID 0000-0001-9665-2609
Li LiSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Haitao WangThe School of Clinical Medical Sciences, Southwest Medical University, Luzhou 646000, China.ORCID 0009-0007-5486-8218
Pengyu MiaoSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Zhihui YangThe School of Clinical Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Mingxi TangSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.ORCID 0000-0003-0715-9631

Funding

Joint Research Fund for Sichuan Province Science and Technology Agency and Southwest Medical University of China 14JC0161the Fund for Luzhou Science and Technology Bureau of Sichuan Province of China 2021-SYF-28the Scientific Research Starting Foundation for Doctor of Southwest Medical University of China 2011204
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by progressive cognitive decline and late-stage neurobehavioral issues marked by amyloid-beta plaques and Tau protein tangles. This study aims to investigate Fibulin-1(FBLN1) gene expression in the hippocampal tissue of

Indexed as

Alzheimer DiseaseComputational BiologyDisease Models, AnimalDNA MethylationHippocampusMice, KnockoutPresenilin-2AnimalsCalcium-Binding ProteinsEpigenesis, GeneticMaleMiceMice, TransgenicPresenilin-1Calcium-Binding ProteinsfibulinPresenilin-1presenilin 1, mousePresenilin-2Psen2 protein, mouseAlzheimer’s diseaseDKO miceDNA methylationDTG miceFBLN1 genesingle-cell sequencing

Identifiers

PMID39201719
PMCPMC11354892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.