Evidence map›Paper›PMID 39202032›Full record

ArticleJournal of personalized medicine2024

Innovative Implementation Strategies for Familial Hypercholesterolemia Cascade Testing: The Impact of Genetic Counseling.

Kelly M Morgan, Gemme Campbell-Salome, Nicole L Walters, Megan N Betts, Andrew Brangan, Alicia Johns, H Lester Kirchner, Zoe Lindsey-Mills, Mary P McGowan, Eric P Tricou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kelly M MorganDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.
Gemme Campbell-SalomeDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.
Nicole L WaltersDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.ORCID 0000-0001-6668-9072
Megan N BettsWellSpan Health, 605 S. George Street, York, PA 17401, USA.
Andrew BranganDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.ORCID 0000-0002-6196-145X
Alicia JohnsBiostatistics Core, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.
H Lester KirchnerDepartment of Population Health Sciences, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.ORCID 0000-0002-2557-6749
Zoe Lindsey-MillsDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.
Mary P McGowanFamily Heart Foundation, 605 E. Colorado Blvd Ste 180, Pasadena, CA 91101, USA.
Eric P TricouFamily Heart Foundation, 605 E. Colorado Blvd Ste 180, Pasadena, CA 91101, USA.
Alanna Kulchak RahmDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.ORCID 0000-0003-2513-9298
Amy C SturmDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.
Laney K JonesDepartment of Genomic Health, Research Institute, Geisinger, 100 N. Academy Avenue, Danville, PA 17922, USA.

Funding

Identification Methods, Patient Activation, and Cascade Testing for FH: IMPACT-FHR01HL148246 · GEISINGER CLINIC · 2025 to 2025
$782k
NHLBI NIH HHS R01 HL148246The National Heart, Lung, And Blood Institute of the National Institutes of Health R01HL148246
6 · The paper itself

Abstract

The IMPACT-FH study implemented strategies (packet, chatbot, direct contact) to promote family member cascade testing for familial hypercholesterolemia (FH). We evaluated the impact of genetic counseling (GC) on medical outcomes, strategy selection, and cascade testing. Probands (i.e., patients with FH) were recommended to complete GC and select sharing strategies. Comparisons were performed for both medical outcomes and strategy selection between probands with or without GC. GEE models for Poisson regression were used to examine the relationship between proband GC completion and first-degree relative (FDR) cascade testing. Overall, 46.3% (81/175) of probands completed GC. Probands with GC had a median LDL-C reduction of -13.0 mg/dL (-61.0, 4.0) versus -1.0 mg/dL (-16.0, 17.0) in probands without GC (

Indexed as

cascade testingfamilial hypercholesterolemiagenetic counselingpopulation genomic screening

Identifiers

PMID39202032
PMCPMC11355397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.