Evidence mapPaperPMID 39202045Full record

ArticleJournal of personalized medicine2024

RIAIT (Italian Registry of Allergen Immunotherapy): Protocol for a New Tool in a New Vision of Disease-Modifying Therapy for Allergists.

Giovanni Costanzo, Cristiano Caruso, Giovanni Paoletti, Ilaria Baglivo, Stefania Colantuono, Diego Bagnasco, Marco Caminati, Mattia Giovannini, Riccardo Castagnoli, Gianenrico Senna and 12 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Giovanni CostanzoPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
Cristiano CarusoUOSD Allergy and Clinical Immunology Unit, Fondazione Policlinico A. Gemelli, IRCCS, 00168 Rome, Italy.ORCID 0000-0001-7631-029X
Giovanni PaolettiPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.ORCID 0000-0003-3953-9225
Ilaria BaglivoUOC Digestive Disease Center CEMAD, Fondazione Policlinico A. Gemelli, IRCCS, 00168 Rome, Italy.ORCID 0000-0003-4041-5182
Stefania ColantuonoUOSD DH Internal Medicine and Digestive Disease, Fondazione Policlinico A. Gemelli, IRCCS, 00168 Rome, Italy.
Diego BagnascoUO Clinica Malattie Respiratorie e Allergologia, IRCCS-AOU San Martino, 16132 Genova, Italy.ORCID 0000-0002-3661-5731
Marco CaminatiAllergy Unit and Asthma Center, Verona Integrated University Hospital, 37134 Verona, Italy.ORCID 0000-0001-7383-1487
Mattia GiovanniniAllergy Unit, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.ORCID 0000-0001-9568-6882
Riccardo CastagnoliPediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-0029-9383
Gianenrico SennaAllergy Unit and Asthma Center, Verona Integrated University Hospital, 37134 Verona, Italy.ORCID 0000-0003-4172-3216
Concetta SirenaRegistro Italiano Allergen Immunotherapy (RIAIT), Via San Gregorio 12, 20124 Milan, Italy.
Maria Angela ToscaAllergy Center, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Giovanni PassalacquaUO Clinica Malattie Respiratorie e Allergologia, IRCCS-AOU San Martino, 16132 Genova, Italy.
Gian Luigi MarsegliaPediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Michele Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giorgio CiprandiAllergy Clinic, Casa di Cura Villa Montallegro, 16145 Genoa, Italy.ORCID 0000-0001-7016-8421
Cristiana IndolfiDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Salvatore BarberiPediatric Unit, ASST-Rhodense, Rho, 20024 Milan, Italy.
Massimo LandiDepartment of Medical Sciences, Graduate School of Allergology and Clinical Immunology, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-7587-4800
Mario Di GioacchinoInstitute for Clinical Immunotherapy and Advanced Biology Treatments, University of Chieti, 66100 Chieti, Italy.ORCID 0000-0002-9224-5886
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.
Enrico HefflerPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy.

Funding

ALK-Abelló (Italy) Unrestricted grantAllergy Therapeutics (Italy) Unrestricted grantAnallergo (Italy) Unrestricted grantHAL Allergy (Italy) Unrestricted grantStallergenes-Greer (Italy) Unrestricted grant
6 · The paper itself

Abstract

Randomized controlled trials have demonstrated responses to clinical parameters, but a significant proportion of allergy patients in real-life settings would have been excluded from such studies. Therefore, real-world research is needed, and there is a growing body of information on allergen immunotherapy's long-term effectiveness and safety. Real-world evidence can be a valuable instrument to better understand the patient's journey and the effectiveness and safety of therapies. For this purpose, a registry will be used for the first time in Italy to evaluate the impact of allergen immunotherapy on several outcomes, including quality of life and disease-related effects in the pediatric and adult allergic population with a socio-economic assessment and respect to real-world health.

Indexed as

allergybiomarkerimmunotherapyreal worldregistry

Identifiers

PMID39202045
PMCPMC11355798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.