Evidence map›Paper›PMID 39203770›Full record

ArticleNutrients2024

The Concentration of Salivary Extracellular Vesicles Is Related to Obesity.

Kristin Röhrborn, Martin Krueger, Mirjam Kalusa, Simone A Fietz, Alexander Ewe, Achim Aigner, Michael Stumvoll, Peter Kovacs, Matthias Blüher, Imke Schamarek and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kristin RöhrbornHelmholtz-Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University of Leipzig and the University Hospital Leipzig AöR, 04103 Leipzig, Germany.ORCID 0000-0003-3805-5499
Martin KruegerInstitute of Anatomy, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.
Mirjam KalusaInstitute of Veterinary Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.
Simone A FietzInstitute of Veterinary Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.
Alexander EweRudolf-Boehm Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-8252-1605
Achim AignerRudolf-Boehm Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-2778-6256
Michael StumvollHelmholtz-Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University of Leipzig and the University Hospital Leipzig AöR, 04103 Leipzig, Germany.
Peter KovacsDepartment of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-0290-5423
Matthias BlüherHelmholtz-Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University of Leipzig and the University Hospital Leipzig AöR, 04103 Leipzig, Germany.ORCID 0000-0003-0208-2065
Imke SchamarekDepartment of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-9178-2962
Kerstin Rohde-ZimmermannHelmholtz-Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University of Leipzig and the University Hospital Leipzig AöR, 04103 Leipzig, Germany.

Funding

Else Kröner-Fresenius-Stiftung 2021_EKEA.30
6 · The paper itself

Abstract

BACKGROUND AND

aimsSaliva is essential for the proper dilution and distribution of taste molecules on the tongue. It harbors extracellular vesicles (EVs), which mediate cell-cell communication. Changes in the composition of salivary EVs may arise under obese conditions and may potentially be involved in taste sensation and dysregulated eating behavior. Therefore, this study addresses the relationship between the size and concentration of salivary EVs and metabolic shifts in obesity or factors of taste sensation. MATERIALS AND

methodsA total of 119 participants in the Obese Taste Bud (OTB) Study were included, who performed a standardized taste test, underwent taste bud density assessment, and were phenotypically characterized for anthropometrics, blood- and saliva adipokine levels, and various metabolic factors. Utilizing size exclusion chromatography followed by ultrafiltration, EVs were extracted from 2 mL of actively secreted saliva. EVs were characterized using nanoparticle tracking analyses, Western blot, and scanning transmission electron microscopy. Finally, group comparisons and bivariate correlation analyses were conducted.

resultsAmong the total cohort, the median size of salivary EVs was 190.05 nm, and the overall concentration ranged from 1.4 × 10

conclusionThe current study provides evidence for the relation between salivary EVs and anthropometric as well as metabolic parameters of obesity. This can provide the basis for further research on the cargo of salivary EVs and how they may influence taste sensation, and may elucidate their potential connection to altered eating habits in obesity.

Indexed as

Extracellular VesiclesObesitySalivaAdultFemaleHumansMaleMiddle AgedTasteTaste BudsYoung Adultextracellular vesiclesobesitysalivataste bud

Identifiers

PMID39203770
PMCPMC11356876

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.