Evidence map›Paper›PMID 39203776›Full record

ArticleNutrients2024

Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren.

Viviana Ramírez, Patricia González-Palacios, Pablo José González-Domenech, Sonia Jaimez-Pérez, Miguel A Baca, Lourdes Rodrigo, María Jesús Álvarez-Cubero, Celia Monteagudo, Luis Javier Martínez-González, Ana Rivas

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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Viviana RamírezDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
Patricia González-PalaciosDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
Pablo José González-DomenechDepartment of Psychiatry, Faculty of Medicine, University of Granada, 18012 Granada, Spain.
Sonia Jaimez-PérezVirgen de las Nieves University Hospital, 18014 Granada, Spain.
Miguel A BacaClinica MenSana, 18009 Granada, Spain.
Lourdes RodrigoDepartment of Legal Medicine, Toxicology and Physical Anthropology, Faculty of Medicine, University of Granada, 18012 Granada, Spain.
María Jesús Álvarez-CuberoGENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government PTS Granada-Avenida de la Ilustración, 114, 18016 Granada, Spain.ORCID 0000-0002-5492-9355
Celia MonteagudoDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.ORCID 0000-0003-0529-379X
Luis Javier Martínez-GonzálezGENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government PTS Granada-Avenida de la Ilustración, 114, 18016 Granada, Spain.ORCID 0000-0003-2202-0662
Ana RivasDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-2143-0750

Funding

Instituto de Salud Carlos III (ISCIII) PI23/01359
6 · The paper itself

Abstract

backgroundNeurodevelopmental disorders (NDDs) like intellectual disability (ID) are highly heritable, but the environment plays an important role. For example, endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and its analogues, have been termed neuroendocrine disruptors. This study aimed to evaluate the influence of different genetic polymorphisms (SNPs) on cognitive function in Spanish schoolchildren according to dietary bisphenol exposure.

methodsA total of 102 children aged 6-12 years old were included. Ten SNPs in genes involved in brain development, synaptic plasticity, and neurotransmission (

results

conclusionsOur findings provide the first proof that exploring the synergistic or additive effects between genetic variability and bisphenol exposure on cognitive function could lead to a better understanding of the multifactorial and polygenic aetiology of NDDs.

Indexed as

Benzhydryl CompoundsBrain-Derived Neurotrophic FactorCognitionEndocrine DisruptorsPhenolsPolymorphism, Single NucleotideAllelesBisphenol A CompoundsChildDietary ExposureFemaleGenotypeHumansMaleMembrane GlycoproteinsMethylenetetrahydrofolate Reductase (NADPH2)BDNF protein, humanBenzhydryl Compoundsbisphenol ABisphenol A CompoundsBrain-Derived Neurotrophic FactorEndocrine DisruptorsHTR2A protein, humanMembrane GlycoproteinsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanOXTR protein, humanPhenolsReceptor, Serotonin, 5-HT2AReceptors, OxytocinReceptor, trkBSynaptosomal-Associated Protein 25tropomyosin-related kinase-B, humanbisphenolscognitive functiondietary exposuregenetic polymorphismneurodevelopmental disorders

Identifiers

PMID39203776
PMCPMC11357571

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.