Evidence map›Paper›PMID 39204049›Full record

ArticleVaccines2024

Anti-RBD Antibody Levels and IFN-γ-Specific T Cell Response Are Associated with a More Rapid Swab Reversion in Patients with Multiple Sclerosis after the Booster Dose of COVID-19 Vaccination.

Alessandra Aiello, Serena Ruggieri, Assunta Navarra, Carla Tortorella, Valentina Vanini, Shalom Haggiag, Luca Prosperini, Gilda Cuzzi, Andrea Salmi, Maria Esmeralda Quartuccio and 9 more

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alessandra AielloTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0003-2681-9383
Serena RuggieriDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Assunta NavarraClinical Epidemiology Unit, National Institute for Infectious Disease Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0002-3662-4312
Carla TortorellaDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Valentina VaniniTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.
Shalom HaggiagDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0002-5569-4121
Luca ProsperiniDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0003-3237-6267
Gilda CuzziTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.
Andrea SalmiTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.
Maria Esmeralda QuartuccioDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Anna Maria Gerarda AlteraTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.
Silvia MeschiLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0003-0924-993X
Giulia MatusaliLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0002-2948-4243
Serena VitaClinical Division of Infectious Diseases, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.
Simonetta GalganiDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Fabrizio MaggiLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Emanuele NicastriClinical Division of Infectious Diseases, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0002-5606-8712
Claudio GasperiniDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.ORCID 0000-0001-8360-4376

Funding

Camera di Commercio, Industria e Artigianato di Roma resolution number 395 on May 25, 2021Ministero della Salute Ricerca Corrente on emerging infections
6 · The paper itself

Abstract

This study investigated the incidence and severity of SARS-CoV-2 breakthrough infections (BIs) and the time to swab reversion in patients with multiple sclerosis (PwMS) after the booster dose of COVID-19 mRNA vaccines. We enrolled 64 PwMS who had completed the three-dose mRNA vaccine schedule and had never experienced COVID-19 before. Among the 64 PwMS, 43.8% had BIs with a median time since the third vaccine dose of 155 days. BIs occurred more frequently in ocrelizumab-treated patients (64.7%). Patients with a relapsing-remitting MS course showed a reduced incidence of BIs compared with those with a primary-progressive disease (

Indexed as

antibody responsebreakthrough infectionCOVID-19 vaccinationdisease-modifying therapiesmultiple sclerosisSARS-CoV-2T cell response

Identifiers

PMID39204049
PMCPMC11359508

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.