Investigation of the Hepatitis-B Vaccine's Immune Response in a Non-Alcoholic Fatty Liver Disease Mouse Model.

Tuğba Kütük, İlyas Onbaşilar, Sevil Oskay-Halaçli, Berrin Babaoğlu, Selda Ayhan, Sıddika Songül Yalçin

Abstract read

In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Therapeutic and chemopreventive potential of melatonin in liver diseases: targeting oxidative stress and inflammatory signaling.Frontiers in pharmacology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tuğba KütükVaccinology Department, Institute of Vaccinology, Hacettepe University, Ankara 06430, Türkiye.

İlyas OnbaşilarVaccinology Department, Institute of Vaccinology, Hacettepe University, Ankara 06430, Türkiye.ORCID 0000-0002-1464-4654

Sevil Oskay-HalaçliDepartment of Basic Sciences of Pediatrics, Institute of Child Health, Hacettepe University, Ankara 06430, Türkiye.

Berrin BabaoğluDepartment of Pathology, Hacettepe University, Ankara 06430, Türkiye.

Selda AyhanDepartment of Basic Sciences of Pediatrics, Institute of Child Health, Hacettepe University, Ankara 06430, Türkiye.ORCID 0000-0002-3525-7995

Sıddika Songül YalçinVaccinology Department, Institute of Vaccinology, Hacettepe University, Ankara 06430, Türkiye.ORCID 0000-0001-9061-4281

Funding

Hacettepe University THD-2022-20913

6 · The paper itself

Abstract

This study aimed to investigate the immunogenicity of the hepatitis B virus (HBV) vaccine by applying a normal and high-dose hepatitis B virus vaccination program in the mice modeling of non-alcoholic fatty liver disease (NAFLD). NAFLD was induced in mouse livers via diet. At the 10-week mark, both groups were divided into 3 subgroups. While the standard dose vaccination program was applied on days 0, 7, and 21, two high-dose programs were applied: one was applied on days 0 and 7, and the other was applied on days 0, 7, and 21. All mice were euthanized. Blood samples from anti-HB titers; T follicular helper, T follicular regulatory, CD27

Indexed as

aluminum hydroxidehepatitis B vaccinationimmunophenotypingmousenonalcoholic fatty liver disease

Identifiers

PMID39204057

DOI10.3390/vaccines12080934

PMCPMC11359425

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.