Evidence map›Paper›PMID 39204231›Full record

ArticlePathogens (Basel, Switzerland)2024

Intraperitoneal Administration of 17-DMAG as an Effective Treatment against

Kercia P Cruz, Antonio L O A Petersen, Marina F Amorim, Alan G S F Pinho, Luana C Palma, Diana A S Dantas, Mariana R G Silveira, Carine S A Silva, Ana Luiza J Cordeiro, Izabella G Oliveira and 11 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kercia P CruzLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0002-4800-2916
Antonio L O A PetersenLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Marina F AmorimLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Alan G S F PinhoLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0001-9557-3861
Luana C PalmaLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Diana A S DantasLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Mariana R G SilveiraLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Carine S A SilvaLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Ana Luiza J CordeiroLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0009-0004-0683-9111
Izabella G OliveiraLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Gabriella B PitaLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Bianca C A SouzaLaboratory of Structural and Molecular Pathology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Gilberto C BomfimLaboratory of Population Genetics and Molecular Evolution, Biology Institute, Federal University of Bahia, Salvador 40170-110, Bahia, Brazil.
Cláudia I BrodskynLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Deborah B M FragaLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0003-4788-0319
Isadora S LimaLaboratory of Structural and Molecular Pathology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0002-5325-5299
Maria B R de SantanaLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Helena M P TeixeiraLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.
Juliana P B de MenezesLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0002-9380-8839
Washington L C SantosLaboratory of Structural and Molecular Pathology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0002-5075-1254
Patrícia S T VerasLaboratory of Host-Parasite Interaction and Epidemiology, Gonçalo Moniz Institute, Fiocruz-Bahia, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0001-8308-9263

Funding

Fundação de Amparo à Pesquisa do Estado da Bahia FAPESB/PPSUS 5186Fundação Oswaldo Cruz 46700287000National Council for Scientific and Technological Development 305235/2019-2National Council for Scientific and Technological Development INCT-DT -465229/2014-0
6 · The paper itself

Abstract

backgroundLeishmaniasis is a significant global public health issue that is caused by parasites from

objectiveThis study evaluates the efficacy of 17-DMAG in treating BALB/c mice from cutaneous leishmaniasis through in vitro and in vivo approaches. MATERIALS AND

methodsWe assessed 17-DMAG's cytotoxic effect on bone marrow-derived macrophages (BMMΦ) and its effects against

results17-DMAG showed selective toxicity [selective index = 432) towards

conclusionsOur findings confirm the potential of 17-DMAG as a viable treatment for cutaneous leishmaniasis and support further research into its mechanisms and potential applications against other infectious diseases.

Indexed as

BenzoquinonesLactams, MacrocyclicLeishmania braziliensisLeishmaniasis, CutaneousMice, Inbred BALB CAnimalsAntiprotozoal AgentsCytokinesDisease Models, AnimalFemaleInjections, IntraperitonealMacrophagesMiceParasite Load17-(dimethylaminoethylamino)-17-demethoxygeldanamycinAntiprotozoal AgentsBenzoquinonesCytokinesLactams, Macrocyclic17-DMAG-HClcutaneous leishmaniasisLeishmania braziliensistreatment

Identifiers

PMID39204231
PMCPMC11357173

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.