Challenges in the case-based surveillance of infectious diseases.

To effectively inform infectious disease control strategies, accurate knowledge of the pathogen's transmission dynamics is required. Since the timings of infections are rarely known, estimates of the infection incidence, which is crucial for understanding the transmission dynamics, often rely on measurements of other quantities amenable to surveillance. Case-based surveillance, in which infected individuals are identified by a positive test, is the predominant form of surveillance for many pathogens, and was used extensively during the COVID-19 pandemic. However, there can be many biases present in case-based surveillance indicators due to, for example test sensitivity, changing testing behaviours and the co-circulation of pathogens with similar symptom profiles. Here, we develop a mathematical description of case-based surveillance of infectious diseases. By considering realistic epidemiological parameters and situations, we demonstrate many of the potential biases in common surveillance indicators based on case-based surveillance data. Crucially, we find that many of these common surveillance indicators (e.g. case numbers, test-positive proportion) are heavily biased by circulating pathogens with similar symptom profiles. Future surveillance strategies could be designed to minimize these sources of bias and uncertainty, providing more accurate estimates of a pathogen's transmission dynamics and, ultimately, more targeted application of public health measures.