Evidence map›Paper›PMID 39206431›Full record

ArticleBrain, behavior, & immunity - health2024

Synergistic effects of GFAP and Aβ42: Implications for white matter integrity and verbal memory across the cognitive spectrum.

Brianne M Bettcher, Dan Lopez Paniagua, Yue Wang, Brice V McConnell, Christina Coughlan, Tara C Carlisle, Ashesh A Thaker, William Lippitt, Christopher M Filley, Victoria S Pelak and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Brianne M BettcherDepartment of Neurology, Behavioral Neurology Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dan Lopez PaniaguaDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yue WangDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brice V McConnellDepartment of Neurology, Behavioral Neurology Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Christina CoughlanDepartment of Neurology, University of Colorado Alzheimer's & Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Tara C CarlisleDepartment of Neurology, Behavioral Neurology Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ashesh A ThakerDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
William LippittDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Christopher M FilleyBehavioral Neurology Section, Departments of Neurology and Psychiatry, University of Colorado Alzheimer's & Cognition Center, Marcus Institute for Brain Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Victoria S PelakDepartment of Neurology, Behavioral Neurology Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Allison L B ShapiroSection of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kate S HeffernanDepartment of Neurology, Behavioral Neurology Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Huntington PotterDepartment of Neurology, University of Colorado Alzheimer's & Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Adriana SolanoDepartment of Neurology, University of Colorado Alzheimer's & Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jada BoydDepartment of Neurology, Behavioral Neurology Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Nichole E CarlsonDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive AgingR01AG058772 · NIA · UNIVERSITY OF COLORADO DENVER · PI BETTCHER, BRIANNE MAGOUIRK · 2019 to 2023
$3.7M
3T MRIS10OD018435 · OD · UNIVERSITY OF COLORADO DENVER · PI TREGELLAS, JASON R · 2014 to 2014
$2.0M
NCATS NIH HHS UL1 TR002535NIA NIH HHS R01 AG058772NIH HHS S10 OD018435
6 · The paper itself

Abstract

Background: Plasma glial fibrillary acidic protein (GFAP), an astrocytic biomarker, has previously been linked with Alzheimer's disease (AD) status, amyloid levels, and memory performance in older adults. The neuroanatomical pathways by which astrogliosis/astrocyte reactivity might impact cognitive outcomes remains unclear. We evaluated whether plasma GFAP and amyloid levels had a synergistic effect on fornix structure, which is critically involved in AD-associated cholinergic pathways. We also examined whether fornix structure mediates associations between GFAP and verbal memory. Methods: In a cohort of both asymptomatic and symptomatic older adults (total n = 99), we assessed plasma GFAP, amyloid-β42 (Aβ42), other AD-related proteins, and vascular markers, and we conducted comprehensive memory testing. Tractography-based methods were used to assess fornix structure with whole brain diffusion metrics to control for diffuse alterations in brain white matter. Results: In individuals in the low plasma amyloid-β42 (Aβ42) group, higher plasma GFAP was associated with lower fractional anisotropy (FA; Discussion: Higher plasma GFAP was associated with altered fornix microstructure in the setting of greater amyloid deposition. We also expanded on our prior GFAP-verbal memory findings by demonstrating that in the low plasma Aβ42 group, left fornix integrity may be a primary white matter conduit for the negative associations between GFAP and verbal memory performance. Overall, these findings suggest that astrogliosis/astrocyte reactivity may play an early, pivotal role in AD pathogenesis, and further demonstrate that high GFAP and low Aβ42 in plasma may reflect a particularly detrimental synergistic role in forniceal-memory pathways.

Indexed as

Alzheimer's diseaseAstrogliosisBiomarkersFornixGFAPVascularVerbal memory

Identifiers

PMID39206431
PMCPMC11357780

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.