Evidence map›Paper›PMID 39207205›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity.

Justine M Mucinski, Giovanna Distefano, John Dubé, Frederico G S Toledo, Paul M Coen, Bret H Goodpaster, James P DeLany

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Justine M MucinskiAdventHealth Orlando, Translational Research Institute, Orlando, FL 32804, USA.ORCID 0000-0003-4432-6638
Giovanna DistefanoAdventHealth Orlando, Translational Research Institute, Orlando, FL 32804, USA.
John DubéSchool of Arts, Science, and Business, Chatham University, Pittsburgh, PA 15232, USA.
Frederico G S ToledoDivision of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-6570-9948
Paul M CoenAdventHealth Orlando, Translational Research Institute, Orlando, FL 32804, USA.ORCID 0000-0002-2805-2115
Bret H GoodpasterAdventHealth Orlando, Translational Research Institute, Orlando, FL 32804, USA.ORCID 0000-0003-1275-5147
James P DeLanyAdventHealth Orlando, Translational Research Institute, Orlando, FL 32804, USA.ORCID 0000-0003-0366-3849

Funding

NIDDK NIH HHS R01 DK091462NIDDK NIH HHS R56 DK091462NIDDK NIH HHS R56DK091462-04A1
6 · The paper itself

Abstract

objectivesNon-Hispanic Black women (BW) have a greater risk of type 2 diabetes (T2D) and insulin resistance (IR) compared to non-Hispanic White women (WW). The mechanisms leading to these differences are not understood, and it is unclear whether synergistic effects of race and obesity impact disease risk. To understand the interaction of race and weight, hepatic and peripheral IR were compared in WW and BW with and without obesity.

methodsHepatic and peripheral IR were measured by a labeled, hyperinsulinemic-euglycemic clamp in BW (n = 32) and WW (n = 32) with and without obesity. Measurements of body composition, cardiorespiratory fitness, and skeletal muscle (SM) respiration were completed. Data were analyzed by mixed model ANOVA.

resultsSubjects with obesity had greater hepatic and peripheral IR and lower SM respiration (P < .001). Despite 14% greater insulin (P = .066), BW tended to have lower peripheral glucose disposal (Rd; P = .062), which was driven by women without obesity (P = .002). BW had significantly lower glucose production (P = .005), hepatic IR (P = .024), and maximal coupled and uncoupled respiration (P < .001) than WW. Maximal coupled and uncoupled SM mitochondrial respiration was strongly correlated with peripheral and hepatic IR (P < .01).

conclusionWhile BW without obesity had lower Rd than WW, race and obesity did not synergistically impact peripheral IR. Paradoxically, WW with obesity had greater hepatic IR compared to BW. Relationships between SM respiration and IR persisted across a range of body weights. These data provide support for therapies in BW, like exercise, that improve SM mitochondrial respiration to reduce IR and T2D risk.

Indexed as

Insulin ResistanceMitochondria, MuscleMuscle, SkeletalObesityAdultBlack or African AmericanBody CompositionCell RespirationDiabetes Mellitus, Type 2FemaleGlucose Clamp TechniqueHumansLiverMiddle AgedOxygen ConsumptionWhite Peopleinsulin sensitivitymitochondrial respirationracial differencesskeletal muscle

Identifiers

PMID39207205
PMCPMC12086411

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.