Evidence map›Paper›PMID 39207736›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Pharmacological inhibition of ENT1 enhances the impact of specific dietary fats on energy metabolism gene expression.

Erwann Pain, Stuart Snowden, Joseph Oddy, Sonia Shinhmar, Yousef M A Alhammad, Jason S King, Annette Müller-Taubenberger, Robin S B Williams

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erwann PainCentre for Biomedical Sciences, Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham TW20 OEX, United Kingdom.
Stuart SnowdenCentre for Biomedical Sciences, Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham TW20 OEX, United Kingdom.
Joseph OddyDepartment of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva 4 CH-1211, Switzerland.
Sonia ShinhmarCentre for Biomedical Sciences, Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham TW20 OEX, United Kingdom.
Yousef M A AlhammadDepartment of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Jason S KingDepartment of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0000-0003-0596-4506
Annette Müller-TaubenbergerDepartment of Cell Biology, Biomedical Center, Ludwig Maximilian University of Munich, Planegg-Martinsried 82152, Germany.ORCID 0000-0003-1163-9232
Robin S B WilliamsCentre for Biomedical Sciences, Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham TW20 OEX, United Kingdom.ORCID 0000-0002-9826-6020

Funding

BBSRC DTP studentship N/AUKRI | Biotechnology and Biological Sciences Research Council (BBSRC) B/V019368/1Vitaflo Ltd N/A
6 · The paper itself

Abstract

Medium chain fatty acids are commonly consumed as part of diets for endurance sports and as medical treatment in ketogenic diets where these diets regulate energy metabolism and increase adenosine levels. However, the role of the equilibrative nucleoside transporter 1 (ENT1), which is responsible for adenosine transport across membranes in this process, is not well understood. Here, we investigate ENT1 activity in controlling the effects of two dietary medium chain fatty acids (decanoic and octanoic acid), employing the tractable model system

Indexed as

Energy MetabolismEquilibrative Nucleoside Transporter 1AdenosineCaprylatesCell ProliferationDictyosteliumDietary FatsDiet, KetogenicGene Expression RegulationMitochondriaAdenosineCaprylatesDietary FatsEquilibrative Nucleoside Transporter 1octanoic aciddecanoic acidDictyostelium discoideumenergy metabolismketogenic dietsmedium chain triglycerides

Identifiers

PMID39207736
PMCPMC11388398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.