Evidence map›Paper›PMID 39207804›Full record

ArticleDiabetes care2024

Effect of SARS-CoV-2 Infection on Incident Diabetes by Viral Variant: Findings From the National COVID Cohort Collaborative (N3C).

Rachel Wong, Margaret A Hall, Talia Wiggen, Steven G Johnson, Jared D Huling, Lindsey E Turner, Kenneth J Wilkins, Hsin-Chieh Yeh, Til Stürmer, Carolyn T Bramante and 3 more

Abstract read
In one paragraph

Article in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rachel WongDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, NY.ORCID 0000-0003-3108-7324
Margaret A HallDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA.
Talia WiggenClinical and Translational Science Institute, University of Minnesota, Minneapolis, MN.
Steven G JohnsonInstitute for Health Informatics, University of Minnesota, Minneapolis, MN.
Jared D HulingDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN.ORCID 0000-0003-0670-4845
Lindsey E TurnerDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN.
Kenneth J WilkinsOffice of the Director, Biostatistics Program/Office of Clinical Research Support, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Hsin-Chieh YehDepartment of Medicine, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-5738-0652
Til StürmerDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Carolyn T BramanteDivision of General Internal Medicine, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0001-5858-2080
John B BuseDivision of Endocrinology and Metabolism, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
Jane ReuschDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.
N3C Consortium

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
CD2H - The National COVID Cohort Collaborative (N3C) IDeA CTR CollaborationU24TR002306 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CHUTE, CHRISTOPHER G, EICHMANN, DAVID A. · 2017 to 2021
$28.9M
Pilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicholette D. Allred · 2020 to 2026
$11.0M
Propensity scores and preventive drug use in the elderlyR01AG056479 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Til Sturmer · 2017 to 2026
$5.0M
Incidence and severity of new onset diabetes associated with SARS-CoV-2 infectionR01DK130351 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DOUGLAS, IVOR SAMUEL, REUSCH, JANE E · 2021 to 2023
$1.5M
Applying causal inference methods to improve estimation of the real-world benefits and harms of lung cancer screening - NCI Diversity SupplementR01CA277756 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Louise Henderson, Jennifer Lund · 2023 to 2026
$1.5M
Self-weighing for Weight Management in Adolescents with ObesityK23DK124654 · NIDDK · UNIVERSITY OF MINNESOTA · PI BRAMANTE, CAROLYN T · 2021 to 2024
$801k
NCATS NIH HHS U24 TR002306NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004405NCATS NIH HHS UM1 TR004406NCI NIH HHS R01 CA277756NIA NIH HHS R01 AG056479NIDDK NIH HHS 3R01DK130351-02S1NIDDK NIH HHS K23 DK124654NIDDK NIH HHS P30 DK124723NIDDK NIH HHS R01 DK130351
6 · The paper itself

Abstract

objectiveThe coronavirus 2019 (COVID-19) pandemic has evolved over time by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, disease severity, treatment, and prevention. There is evidence of an elevated risk of incident diabetes after COVID-19; our objective was to evaluate whether this association is consistent across time and with contemporary viral variants. RESEARCH DESIGN AND

methodsWe conducted a retrospective cohort study using National COVID Cohort Collaborative (N3C) data to evaluate incident diabetes risk among COVID-positive adults compared with COVID-negative patients or control patients with acute respiratory illness (ARI). Cohorts were weighted on demographics, data site, and Charlson comorbidity index score. The primary outcome was the cumulative incidence ratio (CIR) of incident diabetes for each viral variant era.

resultsRisk of incident diabetes 1 year after COVID-19 was increased for patients with any viral variant compared with COVID-negative control patients (ancestral CIR 1.16 [95% CI 1.12-1.21]; Alpha CIR 1.14 [95% CI 1.11-1.17]; Delta CIR 1.17 [95% CI 1.13-1.21]; Omicron CIR 1.13 [95% CI 1.10-1.17]) and control patients with ARI (ancestral CIR 1.17 [95% CI 1.11-1.22]; Alpha CIR 1.14 [95% CI 1.09-1.19]; Delta CIR 1.18 [95% CI 1.11-1.26]; Omicron CIR 1.20 [95% CI 1.13-1.27]). There was latency in the timing of incident diabetes risk with the Omicron variant; in contrast with other variants, the risk presented after 180 days.

conclusionsIncident diabetes risk after COVID-19 was similar across different SARS-CoV-2 variants. However, there was greater latency in diabetes onset in the Omicron variant era.

Indexed as

COVID-19Diabetes MellitusSARS-CoV-2AdultAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedRetrospective Studies

Identifiers

PMID39207804
PMCPMC11417274

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.