Evidence map›Paper›PMID 39209209›Full record

ArticleAmerican journal of ophthalmology2025

Nonredundant Role of Leishmanolysin-Like (Lmln) Zinc-Metallopeptidase in Retinal Homeostasis.

Rafael L Ufret-Vincenty, Dogan Can Kirman, Gizem Ulker-Yilmazer, Bogale Aredo, Sangita Shrestha, Emily Turpin, Seher Yuksel, Yeshumenesh Zegeye, Sara Ludwig, Eva Marie Y Moresco and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. A mutation inMolecular vision · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rafael L Ufret-VincentyDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA. Electronic address: Rafael.Ufret-Vincenty@UTSouthwestern.edu.
Dogan Can KirmanDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Gizem Ulker-YilmazerDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Bogale AredoDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Sangita ShresthaDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Emily TurpinDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Seher YukselDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Yeshumenesh ZegeyeDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Sara LudwigCenter for the Genetics of Host Defense (S.L., E.M.Y.M., B.B.), UT Southwestern Medical Center, Dallas, Texas, USA.
Eva Marie Y MorescoCenter for the Genetics of Host Defense (S.L., E.M.Y.M., B.B.), UT Southwestern Medical Center, Dallas, Texas, USA.
Yu-Guang HeDepartment of Ophthalmology (R.L.U.V., D.C.K., G.U.Y., B.A., S.S., E.T., S.Y., Y.Z., Y.G.H.), UT Southwestern Medical Center, Dallas, Texas, USA.
Bruce BeutlerCenter for the Genetics of Host Defense (S.L., E.M.Y.M., B.B.), UT Southwestern Medical Center, Dallas, Texas, USA.

Funding

Automated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5M
Stem Cell, Organoid and Cell Phenotyping ModuleP30EY030413 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI W MATTHEW PETROLL · 2019 to 2026
$5.9M
Exploring Mechanisms in Retinal Development/Homeostasis, Retinal Immune Surveillance and Diabetic Retinopathy Using Forward GeneticsR01EY033181 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI UFRET-VINCENTY, RAFAEL · 2021 to 2025
$2.2M
NEI NIH HHS P30 EY030413NEI NIH HHS R01 EY033181NIAID NIH HHS R01 AI125581
6 · The paper itself

Abstract

purposeTo determine if Lmln, a Zinc-metallopeptidase, is important for retinal homeostasis.

designBasic research in mouse models of retinal degeneration.

methodsCombining an unbiased N-ethyl-N-nitrosourea mutagenesis pipeline in mice with optical coherence tomography (OCT) screening and automated meiotic mapping, we identified an allele (nemeth) that seemed to be associated with outer nuclear layer (ONL) thinning. Since nemeth was predicted to lead to a nonsense mutation of the Lmln gene, we targeted Lmln using CRISPR/Cas-9 technology and characterized the impact on retinal anatomy and function.

resultsOCT imaging demonstrated an outer retinal degeneration in Lmln

conclusionsOur work revealed a previously unknown essential role for Lmln in maintaining retinal anatomy and function. Further studies using this new model will be aimed at determining the cellular expression of Lmln and its mechanisms of action within the retina.

Indexed as

Disease Models, AnimalElectroretinographyHomeostasisMice, Inbred C57BLRetinal DegenerationTomography, Optical CoherenceAnimalsApoptosisIn Situ Nick-End LabelingMaleMetalloendopeptidasesMiceMice, KnockoutRetinaMetalloendopeptidases

Identifiers

PMID39209209
PMCPMC12067076

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.