Evidence mapPaperPMID 39210401Full record

ArticleRespiratory research2024

Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell-expressed developmentally down-regulated gene 4-Like.

Rui Wang, Rui Wang, Siqi Zhou, Tianya Liu, Jingjing Dang, Qianmin Chen, Jingyu Chen, Zhiping Wang

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Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Rui Wang *Graduate School, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, China.
Rui Wang *Department of Orthopedics, Xuzhou Central Hospital, 199 Jiefang South Road, Quanshan District, Xuzhou, Jiangsu, China.
Siqi Zhou *Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, 321 Zhongshan Road, Drum Tower District, Nanjing, Jiangsu, China.
Tianya LiuDepartment of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, No.99 Huaihai West Road, Xuzhou, Jiangsu, China.
Jingjing DangGraduate School, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, China.
Qianmin ChenDepartment of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, No.99 Huaihai West Road, Xuzhou, Jiangsu, China.
Jingyu ChenGraduate School, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, China.
Zhiping WangGraduate School, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, China. zhpsqxt@126.com.

Funding

Jiangsu Provincial Medical Innovation Center CXZX202211National Natural Science Foundation of China 82270059Natural Science Foundation of Jiangsu Province BK20221222
6 · The paper itself

Abstract

objectivesIn this study, we investigated whether neural precursor cell-expressed developmentally down-regulated gene 4-like (NEDD4L) is the E3 enzyme of angiotensin-converting enzyme 2 (ACE2) and whether NEDD4L degrades ACE2 via ubiquitination, leading to the progression of pulmonary arterial hypertension (PAH).

methodsBioinformatic analyses were used to explore the E3 ligase that ubiquitinates ACE2. Cultured pulmonary arterial smooth muscle cells (PASMCs) and specimens from patients with PAH were used to investigate the crosstalk between NEDD4L and ACE2 and its ubiquitination in the context of PAH.

resultsThe inhibition of ubiquitination attenuated hypoxia-induced proliferation of PASMCs. The levels of NEDD4L were increased, and those of ACE2 were decreased in lung tissues from patients with PAH and in PASMCs. NEDD4L, the E3 ligase of ACE2, inhibited the expression of ACE2 in PASMCs, possibly through ubiquitination-mediated degradation. PAH was associated with upregulation of NEDD4L expression and downregulation of ACE2 expression.

conclusionsNEDD4L, the E3 ubiquitination enzyme of ACE2, promotes the proliferation of PASMCs, ultimately leading to PAH.

Indexed as

Angiotensin-Converting Enzyme 2Nedd4 Ubiquitin Protein LigasesPulmonary Arterial HypertensionUbiquitinationAnimalsCell ProliferationCells, CulturedFemaleHumansMaleMyocytes, Smooth MusclePeptidyl-Dipeptidase APulmonary ArteryRatsRats, Sprague-DawleyACE2 protein, humanAngiotensin-Converting Enzyme 2Nedd4L protein, humanNedd4 Ubiquitin Protein LigasesPeptidyl-Dipeptidase AAngiotensin-converting enzyme 2Neural precursor cell–expressed developmentally down-regulated gene 4-likePulmonary arterial hypertensionPulmonary arterial smooth muscle cellsUbiquitination

Identifiers

PMID39210401
PMCPMC11363581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.