Evidence map›Paper›PMID 39210608›Full record

ArticleAging cell2024

Modeling aging and retinal degeneration with mitochondrial DNA mutation burden.

John Sturgis, Rupesh Singh, Quinn R Caron, Ivy S Samuels, Thomas Micheal Shiju, Aditi Mukkara, Paul Freedman, Vera L Bonilha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Retbindin Dynamically Redistributes to Preserve Retinal Flavin-Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

John SturgisDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0003-0454-8201
Rupesh SinghDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Quinn R CaronDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Ivy S SamuelsDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Thomas Micheal ShijuDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Aditi MukkaraDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Paul FreedmanDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Vera L BonilhaDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-6166-5124

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
Cole Eye Institute Vision Science Training ProgramT32EY024236 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2015 to 2025
$1.0M
Characterizing the role of mitochondrial DNA mutations on retinal degeneration.F31EY035133 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI STURGIS, JOHNATHON BRIAN · 2024 to 2025
$99k
Glut1 and the microvascular complications of diabetesI01BX005844 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI SAMUELS, IVY S · 2022 to 2025
–
Cleveland Clinic Foundation and the Timken FoundationDepartment of Veteran's Affairs BX005844National Institutes of Health - National Eye Institute F31EY035133National Institutes of Health - National Eye Institute P30EY025585National Institutes of Health - National Eye Institute T32EY024236NEI NIH HHS F31 EY035133NEI NIH HHS P30 EY025585NEI NIH HHS T32 EY024236Research to Prevent Blindness
6 · The paper itself

Abstract

Somatic mitochondrial DNA (mtDNA) mutation accumulation has been observed in individuals with retinal degenerative disorders. To study the effects of aging and mtDNA mutation accumulation in the retina, a polymerase gamma (POLG) exonuclease-deficient model, the Polg

Indexed as

AgingDisease Models, AnimalDNA, MitochondrialMutationRetinal DegenerationAnimalsDNA Polymerase gammaElectroretinographyMiceMice, Inbred C57BLMitochondriaOxidative StressRetinaRetinal Pigment EpitheliumTomography, Optical CoherenceDNA, MitochondrialDNA Polymerase gammaPolg protein, mouseD257Amitochondriamitochondrial DNA (mtDNA)polymerase gamma (POLG)retinaretinal degeneration

Identifiers

PMID39210608
PMCPMC11561647

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.