Evidence mapPaperPMID 39211720Full record

ReviewCureus2024

A Comprehensive Review of Emerging Therapies for Type 2 Diabetes and Their Cardiovascular Effects.

Arnaldo J Acosta G, Eesha Chitneni, Claudia Jeanette Manzanares Vidals, Sravani Modumudi, Sobia Hammad, Ashee Verma, Rahul Y Rajesh, Aimen Khaliq, Olaoluwa Adeyemi, Farhat Majeed and 1 more

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arnaldo J Acosta GInternal Medicine, Hospital Universitario Dr. Alfredo Van Grieken, Coro, VEN.
Eesha ChitneniInternal Medicine, MediCiti Institute of Medical Sciences, Hyderabad, IND.
Claudia Jeanette Manzanares VidalsInternal Medicine, General Hospital of Toluca Dr. Nicolas San Juan, Toluca, MEX.
Sravani ModumudiInternal Medicine, Kamineni Academy of Medical Sciences and Research Center, Hyderabad, IND.
Sobia HammadMedicine, Jinnah Medical and Dental College, Karachi, PAK.
Ashee VermaInternal Medicine, Ruxmaniben Deepchand Gardi Medical College, Kota, IND.
Rahul Y RajeshInternal Medicine, Tbilisi State Medical University, Tbilisi, GEO.
Aimen KhaliqMedicine, Liaquat National Hospital and Medical College, Karachi, PAK.
Olaoluwa AdeyemiInternal Medicine, Richmond Gabriel University, Kingstown, VCT.
Farhat MajeedGeneral Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK.
Rucha V GujarInternal Medicine, Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery of inhibitors for sodium-glucose cotransporter 2 (SGLT2) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) has significantly improved type 2 diabetes management. Large-scale clinical studies have shown that both SGLT2 inhibitors and GLP-1 RA enhance cardiovascular health. Benefits include reduced cardiovascular disease risk, lower mortality, fewer heart failure hospitalizations (SGLT2 inhibitors), and stroke prevention (GLP-1 RA). Additionally, these drugs slow chronic kidney disease progression. This comprehensive treatment targets vascular events. Despite differences, both drug classes are crucial. GLP-1 RA mainly reduce stroke risk, while SGLT2 inhibitors alleviate heart failure. Our findings, based on a literature review, will address the renal and cardiac effects of SGLT2 inhibitors and GLP-1 RA in both diabetics and non-diabetics, highlighting their combined benefits for heart conditions.

Indexed as

advanced therapycardio vascular diseasediabetes mellitusglp-1-r agonistsischemic heart diseasessglt2 inhibitors

Identifiers

PMID39211720
PMCPMC11358602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.