Evidence map›Paper›PMID 39212407›Full record

ArticlemBio2024

Allosteric coupling of substrate binding and proton translocation in MmpL3 transporter from

Svitlana Babii, Wei Li, Lixinhao Yang, Anna E Grzegorzewicz, Mary Jackson, James C Gumbart, Helen I Zgurskaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Svitlana BabiiDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Wei LiMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Lixinhao YangSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.
Anna E GrzegorzewiczMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-9212-0258
James C GumbartSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.ORCID 0000-0002-1510-7842
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID 0000-0001-8929-4727

Funding

MmpL3 as a target for novel anti-TB agentsR01AI116525 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2015 to 2024
$5.3M
Intermembrane transport of lipids and metabolites by mycobacterial MmpL protein complexesR01AI187294 · NIAID · UNIVERSITY OF OKLAHOMA · PI Mary Jackson, EDWARD W YU · 2025 to 2026
$1.6M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI116525National Science Foundation (NSF) 2138259,2138286,2138307,2137603,2138296NIAID NIH HHS R01 AI116525NIAID NIH HHS R01 AI187294
6 · The paper itself

Abstract

Infections caused by

Indexed as

Bacterial ProteinsMembrane Transport ProteinsMycobacterium tuberculosisProtonsAllosteric RegulationBiological TransportCord FactorsMycolic AcidsBacterial ProteinsCord FactorsMembrane Transport ProteinsMmpL3 protein, Mycobacterium tuberculosisMycolic AcidsProtonstrehalose monomycolatelipid transport and inhibitionMycobacterium tuberculosisouter membraneproteoliposomestrehalose monomycolate transport

Identifiers

PMID39212407
PMCPMC11481577

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.