Evidence map›Paper›PMID 39212739›Full record

ArticleClinical oral investigations2024

Association of periodontitis with cardiometabolic and haemostatic parameters.

Hester Groenewegen, Jaime F Borjas-Howard, Karina Meijer, Ton Lisman, Arjan Vissink, Fred K L Spijkervet, Willem Nesse, Vladimir Y I G V Tichelaar

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hester Groenewegen *Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands. h.groenewegen@umcg.nl.
Jaime F Borjas-Howard *Department of Haematology, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands.
Karina MeijerDepartment of Haematology, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands.
Ton LismanDepartment of Surgical Research Laboratory, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands.
Arjan VissinkDepartment of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands.
Fred K L SpijkervetDepartment of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands.
Willem NesseDepartment of Oral and Maxillofacial Surgery, Wilhelmina Hospital Assen, Postbus 30001, Assen, 9400 RA, The Netherlands.
Vladimir Y I G V TichelaarDepartment of Haematology, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands.

Funding

Mandema stipendium Man-26082014-14-01
6 · The paper itself

Abstract

objectiveTo investigate the association between periodontitis and cardiometabolic and haemostatic parameters. MATERIALS AND

methodsBetween 2014 and 2019, 54 individuals needing full mouth extraction, and 50 control individuals, were recruited for a combined cross-sectional (individuals versus controls) and longitudinal (individuals before and after extraction) study. Periodontitis severity was measured using the periodontal inflamed surface area (PISA). Blood was drawn to measure the haemostatic (Factor VIII, von Willebrand factor [VWF], endogenous thrombin potential, d-dimer, clot lysis time) and cardiovascular risk (C-reactive protein [CRP], lipid profile) parameters, prior to and 12 weeks post-extraction. The results were analysed group-wise.

resultsThe mean VWF and CRP levels were higher and the high-density lipoprotein levels were lower in the individuals prior to extraction compared to the controls. The VWF was significantly correlated with the PISA (a 21% unit increase in VWF per 1000 mm

conclusionVWF levels are associated with periodontitis severity; they do not improve after full-mouth extraction. Severe periodontitis in control individuals does not induce substantial changes in their haemostatic or inflammatory systems. CLINICAL RELEVANCE: Treatment of periodontitis has been shown to improve the cardiometabolic blood profile of patients with established cardiometabolic disease. However, whether periodontitis treatment improves cardiometabolic and haemostatic profiles in people without cardiometabolic disease is uncertain.

Indexed as

C-Reactive ProteinPeriodontitisvon Willebrand FactorAdultBiomarkersCardiovascular DiseasesCase-Control StudiesCross-Sectional StudiesFactor VIIIFemaleHemostasisHumansLipidsLongitudinal StudiesMaleMiddle AgedBiomarkersC-Reactive ProteinFactor VIIILipidsvon Willebrand FactorCardiovascular diseasesInflammationPeriodontitisTooth extractionVenous thromboembolism

Identifiers

PMID39212739
PMCPMC11364793

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.