Evidence map›Paper›PMID 39214710›Full record

ArticleMolecular pharmacology2024

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor.

Spencer R Pierce, Allison L Germann, Douglas F Covey, Alex S Evers, Joe Henry Steinbach, Gustav Akk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Activation of the human β3 GABABiochemical pharmacology · 2026
    Article
  3. Article
  4. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Spencer R PierceDepartments of Anesthesiology (S.R.P., A.L.G., D.F.C., A.S.E., J.H.S., G.A.), Developmental Biology (D.F.C., A.S.E.), and the Taylor Family Institute for Innovative Psychiatric Research (D.F.C., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St Louis, Missouri.
Allison L GermannDepartments of Anesthesiology (S.R.P., A.L.G., D.F.C., A.S.E., J.H.S., G.A.), Developmental Biology (D.F.C., A.S.E.), and the Taylor Family Institute for Innovative Psychiatric Research (D.F.C., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St Louis, Missouri.
Douglas F CoveyDepartments of Anesthesiology (S.R.P., A.L.G., D.F.C., A.S.E., J.H.S., G.A.), Developmental Biology (D.F.C., A.S.E.), and the Taylor Family Institute for Innovative Psychiatric Research (D.F.C., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St Louis, Missouri.
Alex S EversDepartments of Anesthesiology (S.R.P., A.L.G., D.F.C., A.S.E., J.H.S., G.A.), Developmental Biology (D.F.C., A.S.E.), and the Taylor Family Institute for Innovative Psychiatric Research (D.F.C., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St Louis, Missouri.
Joe Henry SteinbachDepartments of Anesthesiology (S.R.P., A.L.G., D.F.C., A.S.E., J.H.S., G.A.), Developmental Biology (D.F.C., A.S.E.), and the Taylor Family Institute for Innovative Psychiatric Research (D.F.C., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St Louis, Missouri.
Gustav AkkDepartments of Anesthesiology (S.R.P., A.L.G., D.F.C., A.S.E., J.H.S., G.A.), Developmental Biology (D.F.C., A.S.E.), and the Taylor Family Institute for Innovative Psychiatric Research (D.F.C., A.S.E., J.H.S., G.A.), Washington University School of Medicine, St Louis, Missouri akk@morpheus.wustl.edu.ORCID 0000-0001-6677-0655

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2M
Neurosteroid and Cholesterol Binding to Integral Membrane ProteinsR35GM149287 · NIGMS · WASHINGTON UNIVERSITY · PI ALEX S. EVERS · 2023 to 2026
$2.4M
GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM140947NIGMS NIH HHS R35 GM149287NIMH NIH HHS P50 MH122379
6 · The paper itself

Abstract

The γ-aminobutyric acid type A (GABA

Indexed as

NeurosteroidsReceptors, GABA-AXenopus laevisAnimalsFemalegamma-Aminobutyric AcidHumansOocytesPregnanolonePregnenolonegamma-Aminobutyric AcidNeurosteroidsPregnanolonePregnenoloneReceptors, GABA-A

Identifiers

PMID39214710
PMCPMC11493365

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.