Evidence map›Paper›PMID 39215503›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.

Joseph S Reddy, Laura Heath, Abby Vander Linden, Mariet Allen, Katia de Paiva Lopes, Fatemeh Seifar, Erming Wang, Yiyi Ma, William L Poehlman, Zachary S Quicksall and 43 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
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  3. Genetic and Proteomic Investigation of the Smoking-Parkinson's Disease Association.medRxiv : the preprint server for health sciences · 2026
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  15. A primer on copper biology in the brain.Neurobiology of disease · 2025
    Review
  16. Novel set of plasma proteins classifies Alzheimer's dementia in African American individuals with high accuracy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  17. Article
  18. Review
  19. Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration.International journal of molecular sciences · 2025
    Review
  20. An analysis of RNA quality metrics in human brain tissue.Journal of neuropathology and experimental neurology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

53 authors.

Joseph S ReddyMayo Clinic Florida, Jacksonville, Florida, USA.ORCID 0000-0002-1783-4453
Laura HeathSage Bionetworks, Seattle, Washington, USA.
Abby Vander LindenSage Bionetworks, Seattle, Washington, USA.
Mariet AllenMayo Clinic Florida, Jacksonville, Florida, USA.
Katia de Paiva LopesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Fatemeh SeifarEmory University School of Medicine, Atlanta, Georgia, USA.
Erming WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yiyi MaColumbia University Irving Medical Center, New York, New York, USA.
William L PoehlmanSage Bionetworks, Seattle, Washington, USA.
Zachary S QuicksallMayo Clinic Florida, Jacksonville, Florida, USA.
Alexi RunnelsNew York Genome Center, New York, New York, USA.
Yanling WangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Duc M DuongEmory University School of Medicine, Atlanta, Georgia, USA.
Luming YinEmory University School of Medicine, Atlanta, Georgia, USA.
Kaiming XuEmory University School of Medicine, Atlanta, Georgia, USA.
Erica S ModesteEmory University School of Medicine, Atlanta, Georgia, USA.
Anantharaman ShantaramanEmory University School of Medicine, Atlanta, Georgia, USA.
Eric B DammerEmory University School of Medicine, Atlanta, Georgia, USA.
Lingyan PingEmory University School of Medicine, Atlanta, Georgia, USA.
Stephanie R OatmanMayo Clinic Florida, Jacksonville, Florida, USA.
Jo ScanlanSage Bionetworks, Seattle, Washington, USA.
Charlotte HoMayo Clinic Florida, Jacksonville, Florida, USA.
Minerva M CarrasquilloMayo Clinic Florida, Jacksonville, Florida, USA.
Merve AtikMayo Clinic Florida, Jacksonville, Florida, USA.
Geovanna YepezMayo Clinic Florida, Jacksonville, Florida, USA.
Adriana O MitchellMayo Clinic Florida, Jacksonville, Florida, USA.
Thuy T NguyenMayo Clinic Florida, Jacksonville, Florida, USA.
Xianfeng ChenMayo Clinic Florida, Jacksonville, Florida, USA.
David X MarquezRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Hasini ReddyColumbia University Irving Medical Center, New York, New York, USA.
Harrison XiaoColumbia University Irving Medical Center, New York, New York, USA.
Sudha SeshadriThe Glen Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, San Antonio, Texas, USA.
Richard MayeuxColumbia University Irving Medical Center, New York, New York, USA.
Stefan ProkopUniversity of Florida, Gainesville, Florida, USA.
Edward B LeeCenter for Neurodegenerative Disease Brain Bank at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Geidy E SerranoBanner Sun Health Research Institute, Sun City, Arizona, USA.
Thomas G BeachBanner Sun Health Research Institute, Sun City, Arizona, USA.
Andrew F TeichColumbia University Irving Medical Center, New York, New York, USA.
Varham HaroutunianDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Edward J FoxEmory University School of Medicine, Atlanta, Georgia, USA.
Marla GearingEmory University School of Medicine, Atlanta, Georgia, USA.
Aliza WingoEmory University School of Medicine, Atlanta, Georgia, USA.
Thomas WingoEmory University School of Medicine, Atlanta, Georgia, USA.
James J LahEmory University School of Medicine, Atlanta, Georgia, USA.
Allan I LeveyEmory University School of Medicine, Atlanta, Georgia, USA.
Dennis W DicksonMayo Clinic Florida, Jacksonville, Florida, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Philip De JagerColumbia University Irving Medical Center, New York, New York, USA.
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
David BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Nicholas T SeyfriedEmory University School of Medicine, Atlanta, Georgia, USA.
Anna K GreenwoodSage Bionetworks, Seattle, Washington, USA.ORCID 0000-0001-9351-7815
Nilüfer Ertekin-TanerMayo Clinic Florida, Jacksonville, Florida, USA.

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Richard B. LIPTON · 1985 to 2026
$73.9M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6M
Tox-AD: a new multi-institute tri-consortium data resource in the AD Knowledge PortalU24AG061340 · NIA · SAGE BIONETWORKS · PI Laura Michelle Heath, Susheel Varma · 2018 to 2026
$24.6M
Alzheimer's Association Zenith Fellows AwardArizona Biomedical Research CommissionArizona Department of Health ServicesCurePSP FoundationMayo FoundationMichael J. Fox Foundation for Parkinson's ResearchNational Brain and Tissue Resource for Parkinson's Disease and Related Disorders P30AG072980NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG017216NIA NIH HHS P01 AG066597NIA NIH HHS P01AG066597NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG066511NIA NIH HHS P30AG066511NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072979NIA NIH HHS P30AG072979NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG025711NIA NIH HHS R01 AG003949NIA NIH HHS R01 AG017216NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG025711NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG061796NIA NIH HHS R01 AG067501NIA NIH HHS R01 AG072120NIA NIH HHS R01 AG072474NIA NIH HHS R01 AG075827NIA NIH HHS R01 AG079170NIA NIH HHS R01 AG087250NIA NIH HHS RF1 AG062181NIA NIH HHS RF1AG062181NIA NIH HHS U01 AG006576NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG061357NIA NIH HHS U01AG061357NIA NIH HHS U01 AG088425NIA NIH HHS U19 AG062418NIA NIH HHS U19AG062418NIA NIH HHS U19 AG074879NIA NIH HHS U24 AG061340NINDS NIH HHS R01 NS080820NINDS NIH HHS R01-NS080820NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

introductionMulti-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked Black Americans (BA) and Latin Americans (LA), who are disproportionately affected by AD.

methodsTo bridge this gap, Accelerating Medicines Partnership in Alzheimer's Disease (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.

resultsWe generated multi-omics data and curated and harmonized phenotypic data from BA (n = 306), LA (n = 326), or BA and LA (n = 4) brain donors plus non-Hispanic White (n = 252) and other (n = 20) ethnic groups, to establish a foundational dataset enriched for BA and LA participants. This study describes the data available to the research community, including transcriptome from three brain regions, whole genome sequence, and proteome measures. DISCUSSION: The inclusion of traditionally underrepresented groups in multi-omics studies is essential to discovering the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD. HIGHLIGHTS: Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.

Indexed as

Alzheimer DiseaseBrainAgedAged, 80 and overBlack or African AmericanEthnicityFemaleHispanic or LatinoHumansMaleMultiomicsTranscriptomeWhiteAlzheimer's diseasedata descriptormulti‐omicsprecision medicineproteometranscriptomewhole genome sequencing

Identifiers

PMID39215503
PMCPMC11485084

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.