Evidence map›Paper›PMID 39216384›Full record

ArticleBioorganic & medicinal chemistry2024

Proximal fleximer analogues of 2'-deoxy-2'-fluoro-2'-methyl purine nucleos(t)ides: Synthesis and preliminary pharmacokinetic and antiviral evaluation.

Charles D Waters, Evan Carlyle, Viviana Smart, Apurv Rege, Charles J Bieberich, Katherine L Seley-Radtke

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Charles D WatersDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Evan CarlyleDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Viviana SmartDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA.
Apurv RegeDepartment of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA.
Charles J BieberichDepartment of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA.
Katherine L Seley-RadtkeDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA. Electronic address: kseley@umbc.edu.

Funding

Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2022 to 2022
$65.5M
U-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5M
Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Hybrid Nucleoside Scaffolds Targeting FilovirusesR21AI135252 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L · 2018 to 2019
$387k
NIAID NIH HHS R21 AI135252NIAID NIH HHS U19 AI171292NIGMS NIH HHS T32 GM066706NIGMS NIH HHS T34 GM136497
6 · The paper itself

Abstract

In this study, proximal fleximer nucleos(t)ide analogues of Bemnifosbuvir were synthesized and evaluated for their potential to serve as antiviral therapeutics. The final parent flex-nucleoside and ProTide modified flex-nucleoside analogues were tested against several viral families including flaviviruses, filoviruses, and coronaviruses. Modest activity against Zaire Ebola virus was observed at 30 μM for compound ProTide modified analogue. Neither compound exhibited activity for any of the other viruses tested. The parent flex-nucleoside analogue was screened for toxicity in CD-1 mice and showed no adverse effects up to 300 mg/kg, the maximum concentration tested.

Indexed as

Antiviral AgentsAnimalsDose-Response Relationship, DrugHumansMiceMicrobial Sensitivity TestsMolecular StructurePurine NucleosidesStructure-Activity RelationshipAntiviral AgentsPurine NucleosidesEbola VirusFilovirusFleximersNucleosidesProdrugs

Identifiers

PMID39216384
PMCPMC11406706

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.