Evidence map›Paper›PMID 39217263›Full record

ArticlePediatric research2025

Biomarker screening for pulmonary hypertension in VLBW infants at risk for bronchopulmonary dysplasia.

Fernando A Munoz, Amanda Kim, Brendan Kelly, Emma Olson Jackson, Patrick D Evers, Daniel Morrow, Amy McCammond, Brian K Jordan, Brian Scottoline

Abstract read
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Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fernando A MunozDivision of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA. munozf@ohsu.edu.ORCID 0000-0001-8533-0292
Amanda KimDivision of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Brendan KellyDivision of Pediatric Cardiology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Emma Olson JacksonHeart Center, Seattle Children's Hospital, Seattle, WA, USA.
Patrick D EversDivision of Pediatric Cardiology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Daniel MorrowDivision of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Amy McCammondDivision of Pediatric Critical Care, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Brian K Jordan *Division of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Brian Scottoline *Division of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVery low birth weight (VLBW) infants demonstrate altered alveolar and pulmonary vascular development and carry an increased risk of developing bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). Risk stratification for BPD-associated PH (BPD-PH) in at-risk infants may help tailor management, improve outcomes, and optimize resource utilization.

methodsVLBW infants were screened for PH with blood gas measurements, serum NT-proBNP and bicarbonate (HCO3) levels, and echocardiograms if they remained on respiratory support at 34 weeks corrected gestational age. We then tested 11 models using different cutoffs for NT-proBNP and HCO

resultsWe identified PH in 34 of 192 (17.6%) VLBW infants. The median NT-proBNP in VLBWs with PH was 2769 pg/mL versus 917 pg/mL in those without PH (p < 0.0001). A model with NT-proBNP < 950 pg/mL and HCO

conclusionNT-proBNP and HCO IMPACT: NT-proBNP and HCO

Indexed as

Bronchopulmonary DysplasiaHypertension, PulmonaryInfant, Very Low Birth WeightNatriuretic Peptide, BrainPeptide FragmentsBicarbonatesBiomarkersBlood Gas AnalysisEchocardiographyFemaleGestational AgeHumansInfant, NewbornMaleRisk AssessmentRisk FactorsBicarbonatesBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID39217263

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.