ArticleEuropean heart journal2024
Gender and contemporary risk of adverse events in atrial fibrillation.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04700826 (Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation Using Healthcare Data for Pragmatic Research), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation Using Healthcare Data for Pragmatic Research: A Randomised Controlled Trial
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparison of left atrial appendage occlusion with medical treatment for non-valvular atrial fibrillation: systematic review, network and reconstructed individual patient data meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Pooled it
- [Consensus paper on focused transesophageal echocardiography (fTEE) in clinical acute and emergency medicine : From the Commission for Clinical Cardiovascular Medicine of the DGK in cooperation with the DGINA, DGIIN and DGIM].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- [Update of the ESC atrial fibrillation guidelines : From the DGK commission for clinical cardiovascular medicine].Herzschrittmachertherapie & Elektrophysiologie · 2025Guideline
- Clinical Practice Guideline: Preventive Measures and Treatment Options for Atrial Fibrillation.Deutsches Arzteblatt international · 2025Guideline
- Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial.Nature medicine · 2026Trial
- Female sex-related stroke risk in patients with atrial flutter-comparison between CHA2DS2-VA and CHA2DS2-VASc scores.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Development and validation of a prediction model for ischemic stroke recurrence risk in patients with ischemic stroke and atrial fibrillation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Practical Recommendations for Anticoagulation in Patients With Atrial Fibrillation.European journal of clinical investigation · 2026Review
- Patient perspectives on atrial fibrillation management and pharmacist roles in outpatient clinics: a qualitative study.International journal of clinical pharmacy · 2026Article
- Type 1 and type 2 NSTEMI in atrial fibrillation: insights from the HERA-FIB registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Between a Rock and a Hard Place: Balancing Embolic Stroke and Intracerebral Hemorrhage Risk in Left Atrial Appendage Occlusion.Journal of cardiovascular development and disease · 2026Review
- Predicting atrial fibrillation and flutter using BEHRT and identifying multimorbidity patterns using BERTopic.Frontiers in digital health · 2026Article
- Application of Artificial Intelligence in the Early Detection and Management of Atrial Fibrillation: State-of-the-art Review.European cardiology · 2026Review
- Sex differences in the association of social determinants of health and adverse cardiovascular outcomes in patients with atrial fibrillation.Open heart · 2025Article
- Cognitive function disparities among atrial fibrillation patients with varying comorbidities.Journal of geriatric cardiology : JGC · 2025Article
- Artificial Intelligence in the Diagnosis and Management of Atrial Fibrillation.Diagnostics (Basel, Switzerland) · 2025Review
- Integrating gender medicine into modern healthcare: Progress and barriers.European journal of clinical investigation · 2025Review
- Stroke in Dilated Cardiomyopathy: An Autopsy-Based Study of Mechanisms, Topography, and Clinical Implications.Diagnostics (Basel, Switzerland) · 2025Article
- Stroke prevention in atrial fibrillation: A narrative review of current evidence and emerging strategies.European journal of clinical investigation · 2025Review
- Stroke risk stratifications according to CHA2DS2-VASc vs. CHA2DS2-VA in patients with atrial fibrillation: insights from the GLORIA-AF registry.European heart journal. Cardiovascular pharmacotherapy · 2025Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
BACKGROUND AND
aimsThe role of gender in decision-making for oral anticoagulation in patients with atrial fibrillation (AF) remains controversial.
methodsThe population cohort study used electronic healthcare records of 16 587 749 patients from UK primary care (2005-2020). Primary (composite of all-cause mortality, ischaemic stroke, or arterial thromboembolism) and secondary outcomes were analysed using Cox hazard ratios (HR), adjusted for age, socioeconomic status, and comorbidities.
results78 852 patients were included with AF, aged 40-75 years, no prior stroke, and no prescription of oral anticoagulants. 28 590 (36.3%) were women, and 50 262 (63.7%) men. Median age was 65.7 years (interquartile range 58.5-70.9), with women being older and having other differences in comorbidities. During a total follow-up of 431 086 patient-years, women had a lower adjusted primary outcome rate with HR 0.89 vs. men (95% confidence interval [CI] 0.87-0.92; P < .001) and HR 0.87 after censoring for oral anticoagulation (95% CI 0.83-0.91; P < .001). This was driven by lower mortality in women (HR 0.86, 95% CI 0.83-0.89; P < .001). No difference was identified between women and men for the secondary outcomes of ischaemic stroke or arterial thromboembolism (adjusted HR 1.00, 95% CI 0.94-1.07; P = .87), any stroke or any thromboembolism (adjusted HR 1.02, 95% CI 0.96-1.07; P = .58), and incident vascular dementia (adjusted HR 1.13, 95% CI 0.97-1.32; P = .11). Clinical risk scores were only modest predictors of outcomes, with CHA2DS2-VA (ignoring gender) superior to CHA2DS2-VASc for primary outcomes in this population (receiver operating characteristic curve area 0.651 vs. 0.639; P < .001) and no interaction with gender (P = .45).
conclusionsRemoval of gender from clinical risk scoring could simplify the approach to which patients with AF should be offered oral anticoagulation.
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