GLP-1 receptor agonists × cardiovascular events

TrialJournal of the American College of Cardiology2024

The Effect of Semaglutide on Mortality and COVID-19-Related Deaths: An Analysis From the SELECT Trial.

Benjamin M Scirica et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 17,604 people · 2024

Randomised comparison

Reduced deaths

−19%−29% to −7%

Bigger than 6 in 10 for all-cause mortality

As reported

HR 0.81, 95% CI 0.71–0.93 · the paper's word: All-cause mortality

Randomised comparison

Reduced cardiovascular events

−29%−49% to −2%

Bigger than 7 in 10 for cardiovascular events

As reported

HR 0.71, 95% CI 0.51–0.98

Randomised comparison

Reduced deaths

−23%−38% to −5%

Bigger than 7 in 10 for all-cause mortality

As reported

HR 0.77, 95% CI 0.62–0.95 · the paper's word: All-cause mortality

Randomised comparison

Lowered adverse events & safety

−34%−56% to −4%

Bigger than 7 in 10 for adverse events & safety

As reported

HR 0.66, 95% CI 0.44–0.96

+3 more in the walkthrough ↓

Seven numbers in the abstract

the abstract, start to end

had lower rates of all-cause death (HR: 0.81; 95% CI: 0.71-0.93), CV death (HR: 0.85; 95% CI: 0.71-1.01), and non-CV death (HR: 0.77; 95% CI: 0.62-0.95).

sudden cardiac death (98 vs 109; HR: 0.89; 95% CI: 0.68-1.17) and undetermined death (77 vs 90; HR: 0.85; 95% CI: 0.63-1.15).

vs the placebo group (62 vs 87; HR: 0.71; 95% CI: 0.51-0.98).

0.04) or died of COVID-19 (43 vs 65; HR: 0.66; 95% CI: 0.44-0.96).

← favours treatmentfavours comparator →
could be chance
All-cause mortality
HR 0.810.71–0.93
Cardiovascular events
HR 0.890.68–1.17
All-cause mortality
HR 0.850.71–1.01
Cardiovascular events
HR 0.710.51–0.98
Cardiovascular events
HR 0.850.63–1.15
All-cause mortality
HR 0.770.62–0.95
Adverse events & safety
HR 0.660.44–0.96
GLP-1 receptor agonistsCardiovascular eventsAll-cause mortalityAdverse events & safety

GLP-1 receptor agonists × cardiovascular eventshelps?mixed

unlikelylikely
0.500.50 without it

GLP-1 receptor agonists × all-cause mortalityhelps?replicated

unlikelylikely
0.880.86 without it

GLP-1 receptor agonists × adverse events & safetyharms?mixed

unlikelylikely
0.020.02 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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24 papers cite it

2024
2025
2026
this papertrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 39217559