Heterogeneous response of estimated insulin sensitivity indices to metformin in young individuals with type 1 diabetes and different phenotypes.

Luana A L Ramaldes, Sarah S Dos Santos, Patricia M Dualib, Joao R de Sa, Sérgio A Dib

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Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Luana A L RamaldesDepartment of Medicine, Division of Endocrinology, Diabetes Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Caixa Postal 20266 CEP 04022-001, Brazil. luanaramaldes@gmail.com.

Sarah S Dos SantosDepartment of Medicine, Division of Endocrinology, Diabetes Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Caixa Postal 20266 CEP 04022-001, Brazil.

Patricia M DualibDepartment of Medicine, Division of Endocrinology, Diabetes Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Caixa Postal 20266 CEP 04022-001, Brazil.

Joao R de SaDepartment of Medicine, Division of Endocrinology, Diabetes Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Caixa Postal 20266 CEP 04022-001, Brazil.

Sérgio A DibDepartment of Medicine, Division of Endocrinology, Diabetes Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Caixa Postal 20266 CEP 04022-001, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study aimed to investigate whether the response to adding metformin to insulin in young adults with type 1 diabetes (T1D) differs according to weight phenotype and insulin sensitivity index.

methodsA prospective pilot study was conducted over 26 weeks in which insulin plus metformin (2 g/day) was administered to 35 individuals, ranging from normal weight (NW) to overweight (OW) to obese (OB) T1D individuals, to correlate insulin sensitivity indices and other clinical variables.

resultsAt the end of the follow-up period, all groups showed an increase in the eGDR (NW: 7.37 vs 8.16, p = 0.002; OW: 7.28 vs 8.24, p < 0.001; OB: 6.33 vs 7.52 p < 0.001). K

conclusionsThe study showed that eGDR improved independently of basal weight after metformin treatment. However, the K

Indexed as

Insulin resistanceMetforminObesityType 1 diabetes mellitus

Identifiers

PMID39218890

DOI10.1186/s13098-024-01451-4

PMCPMC11367792

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