Evidence map›Paper›PMID 39218975›Full record

ArticleExperimental & molecular medicine2024

Distinct binding conformations of epinephrine with α- and β-adrenergic receptors.

Jian-Shu Lou, Minfei Su, Jinan Wang, Hung Nguyen Do, Yinglong Miao, Xin-Yun Huang

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Cysteine carbon dots/AuAnalytical and bioanalytical chemistry · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jian-Shu Lou *Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-1109-2161
Minfei Su *Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA.
Jinan WangCenter for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66047, USA.
Hung Nguyen DoCenter for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66047, USA.
Yinglong MiaoCenter for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66047, USA.
Xin-Yun HuangDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, 10065, USA. xyhuang@med.cornell.edu.ORCID http://orcid.org/0000-0003-2534-2587

Funding

Molecular Basis of B1-Adrenergic Receptor FunctionR01GM138676 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HUANG, XIN-YUN · 2020 to 2023
$1.5M
Enhanced Sampling of G-Protein-Coupled Receptor-G Protein InteractionsR01GM132572 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, YINGLONG · 2019 to 2023
$1.5M
NIGMS NIH HHS R01 GM132572NIGMS NIH HHS R01 GM138676U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM132572U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM138676
6 · The paper itself

Abstract

Agonists targeting α

Indexed as

EpinephrineMolecular Dynamics SimulationProtein BindingCryoelectron MicroscopyDexmedetomidineHumansProtein ConformationReceptors, Adrenergic, alpha-2Receptors, Adrenergic, betaDexmedetomidineEpinephrineReceptors, Adrenergic, alpha-2Receptors, Adrenergic, beta

Identifiers

PMID39218975
PMCPMC11447022

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.