Evidence map›Paper›PMID 39219947›Full record

ArticleCureus2024

Correlation of Cognitive Status and Atrophy Score in Alzheimer's Disease Among the Bangladeshi Population.

Maliha Hakim, Mahmudul Islam, Mohammad Akter Hossain, Mohammad Nur Uddin, Murshed Baqui, Mashfiqul Hasan, Mohammad Nazrul Islam, Mim Tanzila Mamun, Alif Al Mamun, Redoy Ranjan and 2 more

Abstract read
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In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maliha HakimNeurology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Mahmudul IslamNeurology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Mohammad Akter HossainNeurology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Mohammad Nur UddinNeurology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Murshed BaquiNeurology, Dhaka Medical College, Dhaka, BGD.
Mashfiqul HasanEndocrinology, Diabetes and Metabolism, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Mohammad Nazrul IslamNeuroradiology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Mim Tanzila MamunNeurology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Alif Al MamunPublic Health, Central Queensland Hospital and Health Service, Queensland, AUS.
Redoy RanjanCardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.
Md Abdullah YusufMicrobiology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Ghulam KawnaynNeurology, Combined Military Hospital, Dhaka, BGD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) patients suffer from cognitive dysfunction. This study assessed the structural magnetic resonance imaging (MRI) scoring among Alzheimer's patients (age ≥18 years) to correlate with dementia severity according to mini-mental state exam (MMSE) scores.

methodsThis cross-sectional study evaluated Bangladeshi adult AD patients from January 2018 to December 2022 who attended with subjective memory complaints and fulfilled the diagnostic and statistical manual of mental disorders criteria (DSM 5) for diagnosing dementia. The medial temporal lobe atrophy (MTA) and Koedam's score of the atrophy were measured utilising the 1.5 and 3 Tesla Magnetom symphony MRI systems.

resultsOf the 62 patients enrolled, the majority (39 cases; 62.9%) were aged over 60 years. Males were more predominant than females, with a male-to-female ratio of 2.6:1, and the moderate MMSE group consisted of 35.6% males and 64.7% females (P = 0.01). Further, MTA score severity is paradoxically associated with the MMSE score (P = 0.005). Additionally, we found a statistically significant negative correlation between the severity of the MMSE and only MTA scores (r = -0.350; 95% CI -0.551 to -0.110; P = 0.005).

conclusionStructural magnetic resonance imaging among Alzheimer's patients is significantly correlated with the severity of dementia as per mini-mental state exam scores.

Indexed as

alzheimer's diseasealzheimer’s disease mild cognitive impairment magnetic resonance imaging : neuropathology alzheimer’s disease mild cognitive impairment magnetic resonance imaging : neuropathologyearly onset alzheimer's diseasekoedam’s scoremedial temporal lobe atrophy (mta) scale

Identifiers

PMID39219947
PMCPMC11363468

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.