Evidence map›Paper›PMID 39220091›Full record

ArticleWorld journal of gastrointestinal surgery2024

Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study.

Ioannis Lambrou, Ioannis Mantzoros, Orestis Ioannidis, Dimitrios Tatsis, Elissavet Anestiadou, Vasiliki Bisbinas, Manousos-Georgios Pramateftakis, Efstathios Kotidis, Barbara Driagka, Ourania Kerasidou and 6 more

Abstract read
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In one paragraph

Article in World journal of gastrointestinal surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ioannis LambrouFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Ioannis MantzorosFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Orestis IoannidisFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece. telonakos@hotmail.com.
Dimitrios TatsisFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Elissavet AnestiadouFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Vasiliki BisbinasDepartment of ENT, Royal Cornwall Hospitals NHS Trust, Cornwall TR1 3LJ, United Kingdom.
Manousos-Georgios PramateftakisFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Efstathios KotidisFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Barbara DriagkaFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Ourania KerasidouFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Savvas SymeonidisFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Stefanos BitsianisFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Freideriki SifakiFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Konstantinos AngelopoulosFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Haralabos DemetriadesFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.
Stamatios AngelopoulosFourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowth hormone (GH) plays a crucial role in wound healing and tissue repair in postoperative patients. In particular, colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherapy agents.

aimTo investigate whether GH can improve the healing of a colonic anastomosis following the adverse effects of intraperitoneal administration of 5-fluorouracil (5-FU), bleomycin and cisplatin.

methodsEighty Wistar rats underwent laparotomy and a 1 cm-resection of the transverse colon, followed by an end-to-end anastomosis under general anesthesia. The rats were blindly allocated into four equal groups and administered a different daily intraperitoneal therapeutic regimen for 6 days. The control group (A) received normal saline. Group B received chemotherapy with 5-FU (20 mg/kg), bleomycin (4 mg/kg) and cisplatin (0.7 mg/kg). Group C received GH (2 mg/kg), and group D received the aforementioned combination chemotherapy and GH, as described. The rats were sacrificed on the 7

resultsAll rats survived until the day of sacrifice, with no infections or other complications. A decrease in the body weight of group D rats was observed, not statistically significant compared to group A (

conclusionIntraperitoneal administration of chemotherapy has an adverse effect on the healing process of colonic anastomosis. However, GH can inhibit the deleterious effect of administered chemotherapy agents and induce colonic healing in rats.

Indexed as

AdhesionBursting pressureChemotherapyCollagenColonic anastomosisGrowth hormoneHydroxyprolineInflammationNeoangiogenesis

Identifiers

PMID39220091
PMCPMC11362934

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.