Evidence map›Paper›PMID 39220248›Full record

ReviewNeuro-oncology advances

When genetics and pediatric cancer collide: Understanding and optimizing families' experiences.

Kate Hetherington, Claire E Wakefield, Brittany C McGill, Katherine M Tucker, Mark W Donoghoe, Rebecca Daly, Jacqueline D Hunter, Mandy Ballinger, Noemi A Fuentes-Bolanos, David S Ziegler

Abstract readReview
In one paragraph

Review in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kate HetheringtonBehavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.ORCID https://orcid.org/0000-0002-5457-5462
Claire E WakefieldBehavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Brittany C McGillBehavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Katherine M TuckerHereditary Cancer Centre, Prince of Wales Hospital Nelune Comprehensive Cancer Centre-NCCC, Randwick, New South Wales, Australia.
Mark W DonoghoeStats Central, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Rebecca DalyBehavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Jacqueline D HunterBehavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Mandy BallingerCancer Division, Garvan Institute of Medical Research, Sydney, Australia.
Noemi A Fuentes-BolanosKids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
David S ZieglerKids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.ORCID https://orcid.org/0000-0001-7451-7916

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Advances in our understanding of the genetic basis of childhood cancer, including primary central nervous system cancers, are improving the diagnosis, treatment, and clinical management of pediatric patients. To effectively translate scientific breakthroughs into enhanced clinical care, it is essential we understand and learn from the experiences of patients, families, and health professionals. Methods: This report summarizes findings from 4 Australian psychosocial substudies exploring the perspectives of patients, parents, clinicians, and scientists participating in research related to childhood cancer genetics. Specifically, these studies focus on the psychosocial impact of germline testing in children, surveillance for children with a cancer predisposition syndrome and the perspectives of healthcare professionals who deliver this testing and surveillance. Results: Data presented highlight some of the opportunities and challenges associated with the changing context of genetic predisposition testing for children, adolescents and yound adults with cancer and illustrate how embedding psychosocial data collection in clinical research can answer important questions in the field and inform the design of patient-centric models of care, resources, and workforce training. Conclusions: By embracing these perspectives, we can ensure that advances in genetic research translate into enhanced family experiences, and, ultimately, improved outcomes for children and young people with cancer, and their families.

Indexed as

childhood cancergenetic cancer riskgenetic testing and surveillanceprecision medicinepsychosocial impact

Identifiers

PMID39220248
PMCPMC11364933

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.