Evidence map›Paper›PMID 39220439›Full record

ArticleInternational journal of microbiology2024

Analyzing the Responses of Enteric Bacteria to Neonatal Intensive Care Supplements.

Megan E Waller, Caroline J Eichhorn, Alyssa Gutierrez, John E Baatz, Carol L Wagner, Katherine E Chetta, Melinda A Engevik

Abstract read
In one paragraph

Article in International journal of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan E WallerDepartment of Regenerative Medicine and Cell Biology Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0009-0008-9940-5767
Caroline J EichhornDepartment of Regenerative Medicine and Cell Biology Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0000-0003-4148-9351
Alyssa GutierrezDepartment of Regenerative Medicine and Cell Biology Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0009-0000-1925-7031
John E BaatzDepartment of Pediatrics C.P. Darby Children's Research Institute Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0000-0001-5870-1000
Carol L WagnerDepartment of Pediatrics C.P. Darby Children's Research Institute Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0000-0003-2764-6533
Katherine E ChettaDepartment of Pediatrics C.P. Darby Children's Research Institute Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0000-0002-4669-6723
Melinda A EngevikDepartment of Regenerative Medicine and Cell Biology Medical University of South Carolina, Charleston, USA.ORCID https://orcid.org/0000-0002-9742-9932

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI STEPHEN A DUNCAN · 2020 to 2026
$18.7M
South Carolina Clinical & Translational Research Institute (SCTR)KL2TR001452 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCRAE-CLARK, AIMEE L · 2015 to 2024
$5.9M
Digestive Disease Training ProgramT32DK124191 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI STEPHEN A DUNCAN, Antonis Kourtidis · 2021 to 2026
$1.0M
Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612k
NCATS NIH HHS KL2 TR001452NCATS NIH HHS UL1 TR001450NIDDK NIH HHS K01 DK123195NIDDK NIH HHS T32 DK124191NIGMS NIH HHS P20 GM130457
6 · The paper itself

Abstract

In the neonatal intensive care unit, adequate nutrition requires various enteral products, including human milk and formula. Human milk is typically fortified to meet increased calorie goals, and infants commonly receive vitamin mixes, iron supplements, and less frequently, thickening agents. We examined the growth of 16 commensal microbes and 10 pathobionts found in the premature infant gut and found that formula, freshly pasteurized milk, and donated banked milk generally increased bacterial growth. Fortification of human milk significantly elevated the growth of all microbes. Supplementation with thickeners or NaCl in general did not stimulate additional growth. Vitamin mix promoted the growth of several commensals, while iron promoted growth of pathobionts. These data indicate that pathobionts in the preterm gut have significant growth advantage with preterm formula, fortified donor milk, and supplemented iron and suggest that the choice of milk and supplements may impact the infant gut microbiota.

Identifiers

PMID39220439
PMCPMC11364479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.