ArticleeLife2024
The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Genome-Wide Identification of Transcriptional Start Sites and Candidate Enhancers Regulating Worker Metamorphosis inInsects · 2026Article
- Fruitless produces diverse neuronal sex differences by editing lineage-programmed chromatin landscapes.bioRxiv : the preprint server for biology · 2026Article
- A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.Cell genomics · 2026Article
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- Beyond DNA binding: single C2H2 zinc fingers with adjacent β-strands mediate dimerization in Drosophila transcription factors.Nucleic acids research · 2026Article
- Initiators counteract Polycomb repression and stimulate long-range contacts between enhancers and theOpen biology · 2025Article
- AlphaPulldown2-a general pipeline for high-throughput structural modeling.Bioinformatics (Oxford, England) · 2025Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
BTB (bric-a-brack, Tramtrack, and broad complex) is a diverse group of protein-protein interaction domains found within metazoan proteins. Transcription factors contain a dimerizing BTB subtype with a characteristic N-terminal extension. The Tramtrack group (TTK) is a distinct type of BTB domain, which can multimerize. Single-particle cryo-EM microscopy revealed that the TTK-type BTB domains assemble into a hexameric structure consisting of three canonical BTB dimers connected through a previously uncharacterized interface. We demonstrated that the TTK-type BTB domains are found only in Arthropods and have undergone lineage-specific expansion in modern insects. The
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