Evidence map›Paper›PMID 39222005›Full record

ArticleeLife2024

The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles in

Audrey Le Veve, Mathieu Genete, Christelle Lepers-Blassiau, Chloé Ponitzki, Céline Poux, Xavier Vekemans, Eleonore Durand, Vincent Castric

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Audrey Le VeveUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.ORCID https://orcid.org/0000-0001-5895-370X
Mathieu GeneteUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.
Christelle Lepers-BlassiauUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.
Chloé PonitzkiUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.
Céline PouxUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.
Xavier VekemansUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.
Eleonore DurandUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.
Vincent CastricUniv. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, Lille, France.ORCID https://orcid.org/0000-0002-4461-4915

Funding

Agence Nationale de la Recherche ANR-18-CE02-0020-01European Research Council #648321
6 · The paper itself

Abstract

The long-term balancing selection acting on mating types or sex-determining genes is expected to lead to the accumulation of deleterious mutations in the tightly linked chromosomal segments that are locally 'sheltered' from purifying selection. However, the factors determining the extent of this accumulation are poorly understood. Here, we took advantage of variations in the intensity of balancing selection along a dominance hierarchy formed by alleles at the sporophytic self-incompatibility system of the Brassicaceae to compare the pace at which linked deleterious mutations accumulate among them. We first experimentally measured the phenotypic manifestation of the linked load at three different levels of the dominance hierarchy. We then sequenced and phased polymorphisms in the chromosomal regions linked to 126 distinct copies of

Indexed as

AllelesArabidopsisGenes, DominantGenetic LoadMutationPhenotypeSelection, GeneticSelf-Incompatibility in Flowering Plantsarabidopsis halleriarabidopsis lyratabalancing selectionevolutionary biologygenetic dominancemating typessheltered loadS-locussupergene

Identifiers

PMID39222005
PMCPMC11368402

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.