Evidence map›Paper›PMID 39222277›Full record

Observational studyCardiovascular drugs and therapy2025

Comparison of Ticagrelor with Clopidogrel on Coronary Microvascular Dysfunction Following Acute Myocardial Infarction Using Angiography-Derived Index of Microcirculatory Resistance.

Jiacheng Fang, Yuxuan Zhang, Yiyue Zheng, Delong Chen, Abuduwufuer Yidilisi, Rui Ji, Jianping Xiang, Xinyi Zhang, Jun Jiang

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cardiovascular drugs and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05978726 (Ticagrelor Versus Clopidogrel for Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05978726 completednot on this map

Ticagrelor Versus Clopidogrel for Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction: A Retrospective Study Based on the Angiography-derived Index of Microcirculatory Resistance

TypeobservationalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2017 to 2022Enrolled325ConditionsCoronary Heart DiseaseArmsDual antiplatelet therapy with aspirin and either ticagrelor or clopidogrel
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiacheng Fang *Department of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Yuxuan Zhang *Department of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Yiyue ZhengDepartment of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Delong ChenDepartment of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Abuduwufuer YidilisiDepartment of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Rui JiDepartment of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China.
Jianping XiangArteryFlow Technology Co., Ltd., , Hangzhou, China.
Xinyi Zhang *Department of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China. xinyizhang@zju.edu.cn.
Jun Jiang *Department of Cardiology, The Second Affiliated Hospital School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China. jiang-jun@zju.edu.cn.ORCID 0000-0001-6926-9516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis research aimed to assess the impact of ticagrelor and clopidogrel on coronary microvascular dysfunction (CMD) and prognosis following acute myocardial infarction (AMI), using the angiography-derived index of microcirculatory resistance (angio-IMR) as a non-invasive assessment tool.

methodsIn this retrospective study, angio-IMR was performed to evaluate CMD before and after dual antiplatelet therapy (DAPT) with either ticagrelor (90 mg twice daily, n = 184) or clopidogrel (75 mg once daily, n = 72). The primary endpoint is the improvement of CMD evaluated by angio-IMR (delta angio-IMR) following DAPT. Secondary endpoints included myocardial reinfarction and readmission for heart failure during 2-year follow-up.

resultsCompared with clopidogrel, ticagrelor exhibited a significantly higher delta angio-IMR [- 3.09 (5.14) versus - 1.99 (1.91), P = 0.008], indicating a superior improvement of CMD with ticagrelor treatment. Multivariate Cox regression indicated that ticagrelor treatment was related to a reduced risk of readmission for heart failure [8 (4.3) versus 9 (12.5), adjusted HR = 0.329; 95% CI = 0.116-0.934; P = 0.018] and myocardial reinfarction [7 (3.8) versus 8 (11.1), adjusted HR = 0.349; 95% CI = 0.125-0.975; P = 0.026]. Furthermore, ticagrelor treatment serves as an independent predictor of readmission for heart failure (HR = 0.322; 95% CI = 0.110-0.943; P = 0.039).

conclusionThe results of this study indicate a potential association between ticagrelor treatment and improved CMD, as well as a reduced risk of cardiovascular events, including myocardial reinfarction and readmission for heart failure in AMI patients. Further randomized controlled trials are necessary to confirm the potential benefits of ticagrelor on CMD and cardiovascular prognosis. This clinical trial was registered in www. CLINICALTRIALS: gov (NCT05978726).

Indexed as

ClopidogrelCoronary CirculationMicrocirculationPlatelet Aggregation InhibitorsTicagrelorVascular ResistanceAgedCoronary AngiographyCoronary VesselsFemaleHeart FailureHumansMaleMiddle AgedMyocardial InfarctionPatient ReadmissionClopidogrelPlatelet Aggregation InhibitorsTicagrelorAcute myocardial infarctionClopidogrelCoronary microvascular dysfunctionIndex of microcirculatory resistanceTicagrelor

Identifiers

PMID39222277
PMCPMC12602648

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.