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ArticleTrials2024

SMSs as an alternative to provider-delivered care for unhealthy alcohol use: study protocol for Leseli, an open-label randomised controlled trial of mhGAP-Remote vs mhGAP-Standard in Lesotho.

Jennifer M Belus, Natalie E Johnson, Grace H Yoon, Nadine Tschumi, Malebanye Lerotholi, Irene Falgas-Bague, Tristan T Lee, Pearl Letsoela, Jessica F Magidson, Alain Amstutz and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05925270 (Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes in People With and Without HIV in Lesotho), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05925270 nacompletednot on this map

Substituting SMSs for Provider-delivered Care to Improve Alcohol Use Outcomes in People With and Without HIV in Lesotho

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2023 to 2025Enrolled255ConditionsAlcohol Use Disorder, Mild, Alcohol Use Disorder, ModerateArmsmhGAP-Remote, mhGAP-Standard
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Associations Between Substance Use, Sexual Violence, Mental Distress, and Sexual HIV Risk Behaviors Among Adolescent Girls and Young Women in Lesotho.AIDS education and prevention : official publication of the International Society for AIDS Education · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer M BelusDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland. jennifer.belus@unibas.ch.ORCID http://orcid.org/0000-0003-4091-4889
Natalie E JohnsonDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Grace H YoonDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Nadine TschumiDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Malebanye LerotholiDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Irene Falgas-BagueDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Tristan T LeeDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Pearl LetsoelaMinistry of Health, Maseru, Lesotho.
Jessica F MagidsonDepartment of Psychology, University of Maryland, College Park, USA.
Alain AmstutzDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Niklaus D LabhardtDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe World Health Organization's (WHO) Mental Health Gap Action Programme (mhGAP) is a validated intervention that can be provided by non-specialised healthcare workers to individuals with unhealthy alcohol use. However, it typically requires several in-person sessions at a health facility, which may limit its feasibility and effectiveness in remote settings. This trial compares mhGAP-Standard, a 4 to 6 in-person session intervention, to mhGAP-Remote, a 1 in-person session intervention followed by 8 week of short message service (SMS) in Lesotho. We hypothesise that mhGAP-Remote is superior to mhGAP-Standard in reducing alcohol use (as detailed by the primary and secondary outcomes below).

methodsThis is a two-arm randomised open-label multicentre superiority trial. Participants allocated to mhGAP-Standard receive 4 in-person sessions using motivational interviewing, identifying triggers, and alternative behaviours, with the option of two additional booster sessions. Participants in the mhGAP-Remote arm receive 1 in-person session covering the same content, followed by standardised SMSs over 8 weeks that reinforce intervention content. Non-specialist providers deliver the intervention and receive weekly supervision. Adults (N DISCUSSION: This trial will provide insight into feasibility and effectiveness of a shortened and primarily SMS supported version of mhGAP, which is especially relevant for settings where regular clinic attendance is a major barrier.

trial registrationclinicaltrials.gov NCT05925270 . Approved on June 29th, 2023.

Indexed as

Motivational InterviewingText MessagingAdultAlcohol DrinkingAlcoholismEquivalence Trials as TopicFemaleHumansLesothoMaleMiddle AgedMulticenter Studies as TopicRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeDigital interventionLesothomhGAPProblem alcohol useRandomised controlled trialSMS

Identifiers

PMID39223600
PMCPMC11368011

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.