Evidence map›Paper›PMID 39225224›Full record

ReviewCurrent protein & peptide science2025

Ferritin Hinders Ferroptosis in Non-Tumorous Diseases: Regulatory Mechanisms and Potential Consequences.

Zhongcheng Xie, Qin Hou, Yinling He, Yushu Xie, Qinger Mo, Ziyi Wang, Ziye Zhao, Xi Chen, Tianhong Peng, Liang Li and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current protein & peptide science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhongcheng XieClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Qin HouClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Yinling HeClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Yushu XieClass of Clinical Medicine, University of South China, Hengyang 421001, Hunan, China.
Qinger MoClass of Clinical Medicine, University of South China, Hengyang 421001, Hunan, China.
Ziyi WangClass of Clinical Medicine, University of South China, Hengyang 421001, Hunan, China.
Ziye ZhaoClass of Clinical Medicine, University of South China, Hengyang 421001, Hunan, China.
Xi ChenClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Tianhong PengClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Liang LiClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Wei XieClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.

Funding

College Students' Research Learning and Innovative Experiment Plan in University of South China S202310555044, S202110555307, X202110555529, X202110555516, X202110555523, 20210021512, S202310555044, S202310555046, 202110555098Natural Science Foundation of Hunan Province-Regional Joint Fund 2024JJ7431Scientific Research Project of the Health Commission of Hunan Province 202101021784
6 · The paper itself

Abstract

Ferritin, as an iron storage protein, has the potential to inhibit ferroptosis by reducing excess intracellular free iron concentrations and lipid reactive oxygen species (ROS). An insufficient amount of ferritin is one of the conditions that can lead to ferroptosis through the Fenton reaction mediated by ferrous iron. Consequently, upregulation of ferritin at the transcriptional or posttranscriptional level may inhibit ferroptosis. In this review, we have discussed the essential role of ferritin in ferroptosis and the regulatory mechanism of ferroptosis in ferritin-deficient individuals. The description of the regulatory factors governing ferritin and its properties in regulating ferroptosis as underlying mechanisms for the pathologies of diseases will allow potential therapeutic approaches to be developed.

Indexed as

FerritinsFerroptosisAnimalsHumansIronReactive Oxygen SpeciesFerritinsIronReactive Oxygen SpeciesFerritinferroptosisiron storage proteinpost-transcriptionreactive oxygen species.transcription

Identifiers

PMID39225224

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.